PDF(Pubmed)
Abstract：
This review navigates the intricate relationship between gender, hormonal influences, and the progression of autosomal dominant polycystic kidney disease (ADPKD), highlighting the limited literature on this crucial topic. The study explores the impact of female sex hormones on liver and renal manifestations, uncovering gender-specific differences in disease progression. Actually, hormonal therapy in women with ADPKD remains a challenging issue and is a source of concern regarding its potential impact on disease outcomes, particularly at the hepatic level. Notably, women with ADPKD exhibit a slower renal disease progression compared to men, attributed to hormonal dynamics. This review sheds light on the role of estrogen in regulating pathways of the renin-angiotensin-aldosterone system, revealing its complex interplay and implications for cardiovascular and renal health. Therapeutic considerations for fertile women with ADPKD, including contraception options, are discussed, emphasizing the necessity for personalized approaches. In the postmenopausal phase, the review evaluates the role of hormonal replacement therapy, considering its potential benefits and risks in the context of ADPKD. The review concludes by underscoring the imperative need for tailored treatment approaches for ADPKD patients, considering individual risks and benefits. The scarcity of literature underlines the call for further research to enhance our understanding of optimal hormonal therapies in the context of ADPKD, ultimately paving the way for innovative and personalized therapeutic interventions.
摘要：
这篇综述浏览了性别之间错综复杂的关系，荷尔蒙的影响，常染色体显性遗传性多囊肾病（ADPKD）的进展，突出了关于这一关键主题的有限文献。这项研究探讨了女性性激素对肝肾表现的影响,揭示疾病进展中的性别特异性差异。事实上,激素治疗女性ADPKD仍然是一个具有挑战性的问题，也是人们关注其对疾病结局的潜在影响的一个问题。特别是在肝脏水平。值得注意的是,与男性相比，患有ADPKD的女性肾脏疾病进展较慢，归因于荷尔蒙动力学。本文综述了雌激素在肾素-血管紧张素-醛固酮系统调节通路中的作用。揭示其复杂的相互作用和对心血管和肾脏健康的影响。对患有ADPKD的育龄妇女的治疗考虑，包括避孕选择，讨论，强调个性化方法的必要性。在绝经后阶段,这篇综述评估了激素替代疗法的作用，考虑其在ADPKD背景下的潜在利益和风险。该综述最后强调了为ADPKD患者提供量身定制的治疗方法的必要性。考虑个人风险和收益。文献的匮乏强调了进一步研究的呼吁，以增强我们对ADPKD背景下最佳激素疗法的理解，最终为创新和个性化的治疗干预铺平道路。
