PDF(Pubmed)
Abstract：
(1) Background: Given the global prevalence of glaucoma and the crucial role of intraocular pressure (IOP) reduction in the management of the disease, understanding the immediate effects on retinal structure and function is essential. (2) Methods: This study aimed to assess the effects of preservative-free latanoprost on morphological and functional parameters in treatment-naïve patients with ocular hypertension and open-angle glaucoma. (3) Results: This study showed a significant reduction in IOP by an average of 30.6% after treatment with preservative-free latanoprost. Despite the significant reduction in IOP, no statistically significant changes were observed in the electroretinogram (ERG) nor the optical coherence tomography/angiography (OCT/OCTA) parameters compared to baseline. An exploration of the correlation between IOP changes and various parameters revealed a significant association solely with the macular IPL/INL plexus vessel density (VD) measured with OCTA. (4) Conclusions: This finding suggests a possible association between IOP reduction and changes in the macular microcirculation and provides valuable insights into the differential effects of latanoprost. Acknowledging the study limitations, this study emphasizes the need for larger, longer-term investigations to comprehensively assess the sustained effects of preservative-free latanoprost on both IOP and retinal parameters. In addition, exploring systemic factors and conducting subgroup analyses could improve personalized approaches to glaucoma treatment.
摘要：
（1）背景：鉴于青光眼的全球患病率以及降低眼压（IOP）在疾病管理中的关键作用，了解对视网膜结构和功能的直接影响是至关重要的。（2）方法：本研究旨在评估无防腐剂拉坦前列素对治疗初治高眼压和开角型青光眼患者的形态学和功能参数的影响。(3)结果:该研究显示,在用不含防腐剂的拉坦前列素处理后,IOP显著降低,平均为30.6%。尽管IOP显著降低,与基线相比,视网膜电图(ERG)和光学相干断层扫描/血管造影(OCT/OCTA)参数均未观察到统计学显著变化.对IOP变化与各种参数之间的相关性的探索显示，仅与OCTA测量的黄斑IPL/INL丛血管密度（VD）存在显着关联。（4）结论：这一发现表明IOP降低与黄斑微循环变化之间可能存在关联，并为拉坦前列素的不同作用提供了有价值的见解。承认研究的局限性，这项研究强调需要更大的，长期研究，以全面评估无防腐剂拉坦前列素对IOP和视网膜参数的持续影响。此外,探索系统性因素和进行亚组分析可以改善个性化青光眼治疗方法.
