关键词: antifungal potential antifungal treatment oligosaccharides

Mesh : Chitosan / chemistry pharmacology Antifungal Agents / pharmacology chemistry chemical synthesis Oligosaccharides / chemistry pharmacology Fungi / drug effects Humans Chitin / chemistry pharmacology analogs & derivatives Microbial Sensitivity Tests

来  源:   DOI:10.1002/cbdv.202400044

Abstract:
Chitosan is a cationic polysaccharide derived from chitin deacetylation. This polysaccharide and its oligosaccharides have many biological activities and can be used in several fields due to their favorable characteristics, such as biodegradability, biocompatibility, and nontoxicity. This review aims to explore the antifungal potential of chitosan and chitooligosaccharides along with the conditions used for the activity and mechanisms of action they use to kill fungal cells. The sources, chemical properties, and applications of chitosan and chitooligosaccharides are discussed in this review. It also addresses the threat fungi pose to human health and crop production and how these saccharides have proven to be effective against these microorganisms. The cellular processes triggered by chitosan and chitooligosaccharides in fungal cells, and prospects for their use as potential antifungal agents are also examined.
摘要:
壳聚糖是衍生自几丁质脱乙酰化的阳离子多糖。这种多糖及其寡糖具有许多生物活性,由于其良好的特性,可用于多个领域,如生物降解性,生物相容性,和无毒。这篇综述探讨了壳聚糖和壳寡糖的抗真菌潜力以及它们杀死真菌细胞的活性和作用机制所需的条件。壳聚糖和壳寡糖来源,本文讨论了化学性能和应用。它还解决了真菌对人类健康和作物生产造成的威胁,以及这些糖类如何被证明对这些微生物有效。抗真菌活性的潜在机制,壳聚糖和壳寡糖在真菌细胞中触发的细胞过程,并研究了它们作为潜在抗真菌药的未来前景。
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