PDF(Pubmed)
Abstract：
Polycystic ovary syndrome (PCOS), a hormonal and metabolic disorder manifested in women of reproductive age, is still being treated using drugs with side effects. As an alternative to these drugs, isoflavone, also identified as phytoestrogen, has anti-PCOS activity. Isoflavone can help relieve PCOS symptoms by lowering the level of testosterone, which causes hyperandrogenism, thereby normalizing the menstrual cycle and restoring normal ovarian morphology. Furthermore, isoflavone influences the improvement of the metabolic profile, which changes because of PCOS, as well as the reduction of inflammatory markers and oxidative stress. However, both significant and non-significant results have been generated on the activity of isoflavones in PCOS. The present review aims to discuss the existing literature on the effect of isoflavone on PCOS symptoms based on in vivo and clinical trial studies.
摘要：
多囊卵巢综合征(PCOS),一种出现在育龄妇女身上的荷尔蒙和代谢紊乱，仍在使用有副作用的药物治疗。作为这些药物的替代品，异黄酮,也被确定为植物雌激素，具有抗PCOS活性。异黄酮可以通过降低睾丸激素水平来帮助缓解PCOS症状，导致高雄激素血症，从而使月经周期正常化并恢复正常的卵巢形态。此外，异黄酮影响代谢谱的改善，因为PCOS而改变，以及减少炎症标志物和氧化应激。然而,异黄酮在PCOS中的活性产生了显著和不显著的结果。本综述旨在基于体内和临床试验研究，讨论异黄酮对PCOS症状影响的现有文献。
