PDF(Pubmed)
Abstract：
This case report presents a rare and intriguing clinical scenario involving a 63-year-old male with recurrent left-sided hydroureteronephrosis, hypertension, and hyperlipidemia presenting with fatigue, dyspnea, and weight loss. Laboratory findings revealed anemia, basophilic stippling, spherocytosis, and nucleated red blood cells on the peripheral blood smear, raising concerns for hemolysis. Concomitant iron deficiency anemia led to further investigations, revealing gastritis and a colonic mass. A CT scan revealed splenomegaly with an accessory spleen. The histopathological evaluation identified splenic marginal zone lymphoma (MZL) - a diagnosis supported by flow cytometry. Simultaneously, the patient was found to have a moderately differentiated colorectal adenocarcinoma on colonoscopy. This unique case highlights a rare synchronous occurrence of invasive colonic adenocarcinoma with splenule MZL, an unprecedented finding in medical literature.
摘要：
此病例报告介绍了一种罕见且有趣的临床情况，涉及一名63岁的男性复发性左侧输尿管肾积水，高血压,和表现为疲劳的高脂血症，呼吸困难,和减肥。实验室发现显示贫血,嗜碱性点画，球形细胞增多,外周血涂片上有核红细胞，引起对溶血的担忧。伴随缺铁性贫血导致进一步的调查，显示胃炎和结肠肿块。CT扫描显示脾肿大伴副脾。组织病理学评估确定了脾边缘区淋巴瘤（MZL）-流式细胞术支持的诊断。同时,结肠镜检查发现患者患有中分化结直肠腺癌.这个独特的病例突出了罕见的同步发生的浸润性结肠腺癌与脾MZL，这是医学文献中前所未有的发现。
