METHODS: We conducted a systematic literature search (updated on 23 July 2023) to evaluate safety and efficacy of ciprofol in comparison to propofol in patients undergoing procedures under sedation or GA. We focused on randomized controlled trials (RCTs) only, extrapolating data on onset and offset, and on the side effects and the pain at injection.
RESULTS: The search revealed 14 RCTs, all conducted in China. Eight RCTs studied patients undergoing sedation, and six focused on GA. Bolus of ciprofol for sedation or induction of GA varied from 0.2 to 0.5 mg/kg. In four studies using ciprofol for maintenance of GA, it was 0.8-2.4 mg/kg/h. Ciprofol pharmacokinetics seemed characterized by slower onset and offset as compared to propofol. Pain during injection was less frequent in the ciprofol group in all the 13 studies reporting it. Eight studies reported \"adverse events\" as a pooled outcome, and in five cases, the incidence was higher in the propofol group, not different in the remaining ones. Occurrence of hypotension was the most commonly investigated side effects, and it seemed less frequent with ciprofol.
CONCLUSIONS: Ciprofol for sedation or GA may be safer than propofol, though its pharmacokinetics may be less advantageous.
方法:我们进行了系统的文献检索(2023年7月23日更新),以评估在镇静或GA下进行手术的患者中,与异丙酚相比,使用顺丙酚的安全性和有效性。我们只关注随机对照试验(RCT),推断开始和偏移的数据,以及注射时的副作用和疼痛。
结果:搜索显示14项RCT,都是在中国进行的。八个RCT研究了接受镇静的患者,六个专注于GA。用于镇静或诱导GA的环丙泊酚的剂量为0.2至0.5mg/kg。在使用顺丙泊酚维持GA的四项研究中,0.8-2.4mg/kg/h。与丙泊酚相比,环丙泊酚的药代动力学特征似乎是起效和抵消较慢。在所有13项报告的研究中,环丙泊酚组注射过程中的疼痛频率较低。八项研究报告了“不良事件”作为汇总结果,在五种情况下,异丙酚组的发病率较高,其余的没有什么不同。低血压的发生是最常见的副作用,使用顺丙泊酚的频率似乎较低。
结论:用于镇静或GA的环丙泊酚可能比丙泊酚更安全,尽管它的药代动力学可能不太有利。