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Abstract：
METHODS: We aimed to investigate the clinical characteristics, outcomes, and mortality predictors in patients with acute pulmonary embolism (PE). Adult patients who were admitted to the Armed Forces Hospital Southern Region, Khamis Mushait, a large tertiary hospital in Southern Saudi Arabia, with the diagnosis of acute PE were retrospectively examined for the predictors of one-year mortality.
RESULTS: The overall in-hospital mortality was 15.6% among 212 patients. In univariate analysis, only age was significantly associated with increased early mortality, whereas age, obesity, presence of active malignancy, hypertension, use of thrombolytics, and Simplified Pulmonary Embolism Severity Index (sPESI) were significantly associated with increased late mortality. By use of binary logistic regression, the presence of obesity (HR 6.010, 95%CI 0.048-16.853, p=0.030), active malignancy (HR 3.040, 95%CI 1.147-8.059, p=0.025), and the use of thrombolytics (HR 8.074, 95%CI 2.719-23.977, p<0.001), were independently significant factors for late (overall) mortality, respectively.
CONCLUSIONS: Among Saudi Arabian patients in the Southern Region, our data show that age is an independent factor for increased early and late mortality. The presence of obesity, active malignancy, and the use of thrombolytics, were independently significant factors for increased late (one-year) mortality. These factors should be taken into account for risk stratification and decisions on tailored management of patients with PE. Further prospective multicenter studies are needed.
RESULTS: The overall in-hospital mortality was 15.6% among 212 patients. In univariate analysis, only age was significantly associated with increased early mortality, whereas age, obesity, presence of active malignancy, hypertension, use of thrombolytics, and Simplified Pulmonary Embolism Severity Index (sPESI) were significantly associated with increased late mortality. By use of binary logistic regression, the presence of obesity (HR 6.010, 95%CI 0.048-16.853, p=0.030), active malignancy (HR 3.040, 95%CI 1.147-8.059, p=0.025), and the use of thrombolytics (HR 8.074, 95%CI 2.719-23.977, p<0.001), were independently significant factors for late (overall) mortality, respectively.
CONCLUSIONS: Among Saudi Arabian patients in the Southern Region, our data show that age is an independent factor for increased early and late mortality. The presence of obesity, active malignancy, and the use of thrombolytics, were independently significant factors for increased late (one-year) mortality. These factors should be taken into account for risk stratification and decisions on tailored management of patients with PE. Further prospective multicenter studies are needed.
摘要：
方法：我们旨在研究临床特征，结果，急性肺栓塞（PE）患者的死亡率预测因子。南部地区武装部队医院收治的成年患者，KhamisMushait,沙特阿拉伯南部的一家大型三级医院，对诊断为急性PE的患者进行1年死亡率预测因素的回顾性研究.
结果：在212例患者中，总的住院死亡率为15.6%。在单变量分析中，只有年龄与早期死亡率增加显著相关,而年龄,肥胖，存在活动性恶性肿瘤，高血压,使用溶栓剂，简化肺栓塞严重程度指数(sPESI)与晚期死亡率增加显著相关.通过使用二元逻辑回归，肥胖的存在（HR6.010，95CI0.048-16.853，p=0.030），活动性恶性肿瘤（HR3.040，95CI1.147-8.059，p=0.025），和溶栓剂的使用（HR8.074，95CI2.719-23.977，p<0.001），是晚期（总体）死亡率的独立重要因素，分别。
结论：在南部地区的沙特阿拉伯患者中，我们的数据显示,年龄是早期和晚期死亡率增加的独立因素.肥胖的存在，活动性恶性肿瘤，使用溶栓剂，是晚期（一年）死亡率增加的独立重要因素。在对PE患者进行个性化管理的风险分层和决策时，应考虑这些因素。需要进一步的前瞻性多中心研究。
结果：在212例患者中，总的住院死亡率为15.6%。在单变量分析中，只有年龄与早期死亡率增加显著相关,而年龄,肥胖，存在活动性恶性肿瘤，高血压,使用溶栓剂，简化肺栓塞严重程度指数(sPESI)与晚期死亡率增加显著相关.通过使用二元逻辑回归，肥胖的存在（HR6.010，95CI0.048-16.853，p=0.030），活动性恶性肿瘤（HR3.040，95CI1.147-8.059，p=0.025），和溶栓剂的使用（HR8.074，95CI2.719-23.977，p<0.001），是晚期（总体）死亡率的独立重要因素，分别。
结论：在南部地区的沙特阿拉伯患者中，我们的数据显示,年龄是早期和晚期死亡率增加的独立因素.肥胖的存在，活动性恶性肿瘤，使用溶栓剂，是晚期（一年）死亡率增加的独立重要因素。在对PE患者进行个性化管理的风险分层和决策时，应考虑这些因素。需要进一步的前瞻性多中心研究。
