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Abstract：
Stauffer syndrome is a non-metastatic, nephrogenic, hepatic dysfunction syndrome that is linked to extrahepatic paraneoplastic tumors. It manifests with varying clinical signs that include jaundice, anicteric transaminitis, elevated alkaline phosphatase, thrombocytosis, elevated erythrocyte sedimentation rate, prolonged prothrombin time, and, in some cases, hepatosplenomegaly in the absence of hepatobiliary obstruction. Stauffer syndrome is mostly associated with renal cell carcinoma, but research shows other solid malignancies are implicated with this syndrome. Stauffer syndrome is characterized by elevated liver function tests, specifically those that indicate the presence of cholestasis with or without hepatosplenomegaly. The abnormality is not due to tumor infiltration but rather indirect paraneoplastic effects that are poorly understood. Additionally, emerging literature also supports the association of syndrome of inappropriate antidiuretic hormone secretion (SIADH) secondary to malignancy in the setting of elevated interleukin-6. In this article, we present the case of a 76-year-old patient with SIADH and abnormalities in liver function tests in the context of Stauffer syndrome tied to renal cell carcinoma coinciding with liposarcoma.
摘要：
Stauffer综合征是非转移性的,肾性,与肝外副肿瘤有关的肝功能障碍综合征。它表现为不同的临床症状，包括黄疸，无黄疸转氨酶,碱性磷酸酶升高，血小板增多症,红细胞沉降率升高，凝血酶原时间延长，and,在某些情况下,无肝胆梗阻的肝脾肿大。Stauffer综合征主要与肾细胞癌有关，但是研究表明，其他实体恶性肿瘤也与这种综合征有关。Stauffer综合征的特点是肝功能检查升高，特别是那些表明有或没有肝脾肿大的胆汁淤积的存在。异常不是由于肿瘤浸润，而是由于人们知之甚少的间接副肿瘤效应。此外,新出现的文献还支持在白细胞介素-6升高的情况下,继发于恶性肿瘤的抗利尿激素分泌不当综合征(SIADH)的相关性.在这篇文章中,我们介绍了一例76岁的SIADH患者,在Stauffer综合征与肾细胞癌并发脂肪肉瘤相关的情况下,肝功能检查异常.
