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Abstract：
UNASSIGNED: Whether a dilated intrahepatic bile duct (IHBD) has any effect on the prognosis of choledochal cyst (CC) remains controversial. We aimed to summarize the clinical characteristics and prognosis of CC with IHBD dilatation.
UNASSIGNED: One hundred ninety-two children diagnosed with CC were identified, including 127 without IHBD dilatation (group A) and 65 with IHBD dilatation (group B). A retrospective analysis was performed to explore the clinical characteristics and prognosis of CC with IHBD dilatation based on clinical indices, symptoms, and complications.
UNASSIGNED: Compared with group A, incidences of jaundice and fever were higher in group B (P = 0.010 and P = 0.033). Preoperative total bilirubin, direct bilirubin, and indirect bilirubin were increased in group B compared to group A (P = 0.005, P < 0.001, and P = 0.014), as were preoperative ALT, AST, γ-GT, and total bile acid (P = 0.006, P = 0.025, P < 0.001, and P = 0.024). The risk of liver fibrosis or cirrhosis was significantly increased for group B compared with group A (P = 0.012) and also occurred earlier in group B (P = 0.006). In the dilated IHBDs, 95.4% (62 of 65) recovered to normal, and more than half of dilated IHBDs (37 of 65) recovered to normal in 1 week.
UNASSIGNED: Most IHBDs can recover to normal postoperatively in a short time, and proactive treatment is recommended for CC patients with IHBD dilatation for significant abnormal liver functions.
UNASSIGNED: One hundred ninety-two children diagnosed with CC were identified, including 127 without IHBD dilatation (group A) and 65 with IHBD dilatation (group B). A retrospective analysis was performed to explore the clinical characteristics and prognosis of CC with IHBD dilatation based on clinical indices, symptoms, and complications.
UNASSIGNED: Compared with group A, incidences of jaundice and fever were higher in group B (P = 0.010 and P = 0.033). Preoperative total bilirubin, direct bilirubin, and indirect bilirubin were increased in group B compared to group A (P = 0.005, P < 0.001, and P = 0.014), as were preoperative ALT, AST, γ-GT, and total bile acid (P = 0.006, P = 0.025, P < 0.001, and P = 0.024). The risk of liver fibrosis or cirrhosis was significantly increased for group B compared with group A (P = 0.012) and also occurred earlier in group B (P = 0.006). In the dilated IHBDs, 95.4% (62 of 65) recovered to normal, and more than half of dilated IHBDs (37 of 65) recovered to normal in 1 week.
UNASSIGNED: Most IHBDs can recover to normal postoperatively in a short time, and proactive treatment is recommended for CC patients with IHBD dilatation for significant abnormal liver functions.
摘要：
■肝内胆管扩张（IHBD）是否对胆总管囊肿（CC）的预后有任何影响仍存在争议。我们旨在总结CC伴IHBD扩张的临床特征和预后。
■确认了92名被诊断为CC的儿童，其中127例无IHBD扩张（A组）和65例有IHBD扩张（B组）。回顾性分析基于临床指标探讨CC伴IHBD扩张的临床特点及预后,症状,和并发症。
■与A组相比，B组黄疸和发热发生率较高(P=0.010和P=0.033)。术前总胆红素,直接胆红素,与A组相比，B组的间接胆红素升高（P=0.005，P<0.001，P=0.014），术前ALT，AST,γ-GT,总胆汁酸(P=0.006,P=0.025,P<0.001,P=0.024)。与A组相比，B组肝纤维化或肝硬化的风险显着增加（P=0.012），并且在B组中也更早发生（P=0.006）。在扩张的IHBDs中，95.4%（65人中的62人）恢复正常，超过一半的扩张的IHBDs（65个中的37个）在1周内恢复正常。
■大多数IHBDs术后可以在短时间内恢复正常，对于IHBD扩张的CC患者，建议积极治疗。
■确认了92名被诊断为CC的儿童，其中127例无IHBD扩张（A组）和65例有IHBD扩张（B组）。回顾性分析基于临床指标探讨CC伴IHBD扩张的临床特点及预后,症状,和并发症。
■与A组相比，B组黄疸和发热发生率较高(P=0.010和P=0.033)。术前总胆红素,直接胆红素,与A组相比，B组的间接胆红素升高（P=0.005，P<0.001，P=0.014），术前ALT，AST,γ-GT,总胆汁酸(P=0.006,P=0.025,P<0.001,P=0.024)。与A组相比，B组肝纤维化或肝硬化的风险显着增加（P=0.012），并且在B组中也更早发生（P=0.006）。在扩张的IHBDs中，95.4%（65人中的62人）恢复正常，超过一半的扩张的IHBDs（65个中的37个）在1周内恢复正常。
■大多数IHBDs术后可以在短时间内恢复正常，对于IHBD扩张的CC患者，建议积极治疗。
