PDF(Pubmed)
Abstract：
UNASSIGNED: There is limited data on the effects of norepinephrine on neonatal outcomes and maternal complications relative to other vasopressors. The study aimed to compare neonatal outcomes and maternal complications after bolus intravenous doses of phenylephrine and norepinephrine for post-spinal hypotension in elective caesarean section women.
UNASSIGNED: This randomised study was done on 100 elective caesarean section women under spinal anaesthesia. Block randomisation divided women into two groups to receive intravenous phenylephrine 50 μg bolus (Group A) or norepinephrine 5 μg bolus (Group B) following post-spinal hypotension. Groups were evaluated and compared for umbilical arterial blood gas analysis, birth weight, APGAR (appearance, pulse, grimace, activity, and respiration) score, maternal haemodynamics, and complications. Kolmogorov-Smirnov and Shapiro-Wilk tests were used to verify data normality. Independent samples t-test or Mann-Whitney U test was employed to compare continuous variables based on data normality, and the Chi-square test was used to determine categorical variable associations.
UNASSIGNED: Demographic characteristics of women were found to be comparable between groups. Umbilical arterial potential of hydrogen, partial pressure of oxygen, partial pressure of carbon dioxide, base excess, bicarbonate, birth weight, and APGAR scores were comparable across groups, showing no significant differences (P > 0.05). Groups had similar maternal haemodynamic characteristics and episodes of nausea, vomiting, and chest pain across groups without statistical significance (P > 0.05).
UNASSIGNED: No notable distinction was found between neonatal outcomes and maternal complications between phenylephrine and norepinephrine bolus regimens. Norepinephrine can be used as an alternative to phenylephrine post-spinal hypotension in women undergoing elective caesarean section.
UNASSIGNED: This randomised study was done on 100 elective caesarean section women under spinal anaesthesia. Block randomisation divided women into two groups to receive intravenous phenylephrine 50 μg bolus (Group A) or norepinephrine 5 μg bolus (Group B) following post-spinal hypotension. Groups were evaluated and compared for umbilical arterial blood gas analysis, birth weight, APGAR (appearance, pulse, grimace, activity, and respiration) score, maternal haemodynamics, and complications. Kolmogorov-Smirnov and Shapiro-Wilk tests were used to verify data normality. Independent samples t-test or Mann-Whitney U test was employed to compare continuous variables based on data normality, and the Chi-square test was used to determine categorical variable associations.
UNASSIGNED: Demographic characteristics of women were found to be comparable between groups. Umbilical arterial potential of hydrogen, partial pressure of oxygen, partial pressure of carbon dioxide, base excess, bicarbonate, birth weight, and APGAR scores were comparable across groups, showing no significant differences (P > 0.05). Groups had similar maternal haemodynamic characteristics and episodes of nausea, vomiting, and chest pain across groups without statistical significance (P > 0.05).
UNASSIGNED: No notable distinction was found between neonatal outcomes and maternal complications between phenylephrine and norepinephrine bolus regimens. Norepinephrine can be used as an alternative to phenylephrine post-spinal hypotension in women undergoing elective caesarean section.
摘要：
■关于去甲肾上腺素相对于其他血管加压药对新生儿结局和母体并发症的影响的数据有限。该研究旨在比较选择性剖腹产妇女静脉推注剂量的去氧肾上腺素和去甲肾上腺素治疗脊髓后低血压后的新生儿结局和产妇并发症。
■这项随机研究是在脊柱麻醉下对100名择期剖腹产妇女进行的。在脊髓后低血压后，将妇女随机分为两组，分别接受静脉内注射去氧肾上腺素50μg推注（A组）或去甲肾上腺素5μg推注（B组）。各组进行脐动脉血气分析的评估和比较，出生体重,APGAR(外观,脉搏,鬼脸,活动,和呼吸)评分，产妇血流动力学,和并发症。使用Kolmogorov-Smirnov和Shapiro-Wilk检验来验证数据的正态。采用独立样本t检验或Mann-WhitneyU检验根据数据正态比较连续变量，并使用卡方检验确定分类变量关联。
■发现女性的人口统计学特征在组间具有可比性。氢的脐动脉电位，氧分压,二氧化碳分压,碱过量，碳酸氢盐,出生体重,APGAR评分在各组之间具有可比性，差异无统计学意义(P>0.05)。各组有相似的母体血流动力学特征和恶心发作，呕吐,胸痛组间无统计学意义(P>0.05)。
■在去氧肾上腺素和去甲肾上腺素推注方案中，新生儿结局和产妇并发症之间没有发现显著差异。去甲肾上腺素可作为选择性剖腹产妇女脊髓后低血压的替代药物。
■这项随机研究是在脊柱麻醉下对100名择期剖腹产妇女进行的。在脊髓后低血压后，将妇女随机分为两组，分别接受静脉内注射去氧肾上腺素50μg推注（A组）或去甲肾上腺素5μg推注（B组）。各组进行脐动脉血气分析的评估和比较，出生体重,APGAR(外观,脉搏,鬼脸,活动,和呼吸)评分，产妇血流动力学,和并发症。使用Kolmogorov-Smirnov和Shapiro-Wilk检验来验证数据的正态。采用独立样本t检验或Mann-WhitneyU检验根据数据正态比较连续变量，并使用卡方检验确定分类变量关联。
■发现女性的人口统计学特征在组间具有可比性。氢的脐动脉电位，氧分压,二氧化碳分压,碱过量，碳酸氢盐,出生体重,APGAR评分在各组之间具有可比性，差异无统计学意义(P>0.05)。各组有相似的母体血流动力学特征和恶心发作，呕吐,胸痛组间无统计学意义(P>0.05)。
■在去氧肾上腺素和去甲肾上腺素推注方案中，新生儿结局和产妇并发症之间没有发现显著差异。去甲肾上腺素可作为选择性剖腹产妇女脊髓后低血压的替代药物。
