PDF(Pubmed)
Abstract：
Sickle cell disease is characterised by episodes of vaso-occlusive crisis, a painful complication. Regional anaesthesia has shown promising results in reducing opioid consumption and pain scores. Patients with vaso-occlusive crises who underwent regional anaesthesia in the paediatric intensive care unit were studied. Data regarding pain location, regional analgesia technique, the local anaesthetic used and dose, daily opioid consumption, daily pain scores, use of adjuvants and complications were recorded. The primary outcome was to evaluate the effect of regional anaesthesia on opioid consumption. In this study, we describe 10 cases, referring to six paediatric patients with the vaso-occlusive crisis who underwent regional anaesthesia for severe pain and were unresponsive to increasing doses of opioids. Six cases received epidural analgesia, three continuous peripheral nerve blocks and one received both techniques. Opioid consumption was reduced (58%), and pain scores decreased (72%), both statistically significant reductions.
摘要：
镰状细胞病以血管闭塞危象发作为特征,痛苦的并发症.区域麻醉在减少阿片类药物消耗和疼痛评分方面显示出有希望的结果。研究了在儿科重症监护病房接受区域麻醉的血管闭塞危象患者。有关疼痛位置的数据，局部镇痛技术，使用的局部麻醉剂和剂量，每日阿片类药物消费量，每日疼痛评分，记录佐剂的使用情况和并发症.主要结果是评估区域麻醉对阿片类药物消耗的影响。在这项研究中,我们描述了10个案例，涉及6名患有血管闭塞危象的儿科患者，他们因严重疼痛而接受了区域麻醉，并且对增加剂量的阿片类药物无反应。6例硬膜外镇痛，三个连续的周围神经阻滞和一个接受这两种技术。阿片类药物消耗减少（58%），疼痛评分下降（72%），两者都有统计学意义的下降。
