PDF(Pubmed)
Abstract：
UNASSIGNED: To investigate the contrast sensitivity function (CSF) changes in simple high myopia (SHM) and evaluate the correlations between these changes with the early changes in the retinal microstructure.
UNASSIGNED: This prospective study comprised 81 subjects, 20 with emmetropia (EM), 26 with low myopia and moderate myopia (LM/MM), and 35 with SHM. The area under the log CSF curve (AULCSF) and the cut-off spatial frequency (Cut-off SF) were employed as measures of CSF. Adaptive optics (AO) was employed to quantify the cone density, spacing, and regularity. The thickness and blood flow of the retinal sublayers were determined from vertical and horizontal optical coherence tomography angiography (OCTA) A-scans. Swept-source optical coherence tomography (SS-OCT) was employed to analyze the choroidal thickness (CT) and choroidal vascularity using a custom algorithm. Differences in the retinal and choroidal parameters, cone distribution, AULCSF, and Cut-off SF were compared among the three groups. Multivariate linear mixed models were used to elucidate the associations between photoreceptor morphological alterations, retinal and choroidal parameters, and AULCSF.
UNASSIGNED: The AULCSF and Cut-off SF were significantly lower in the SHM group compared to the EM and LM groups (p < 0.05). The SHM group had less cone density, larger cone spacing, and lower cone regularity than the EM and LM/MM groups (p < 0.05). Moreover, the thickness of the inner segment of photoreceptors (IS), retinal pigment epithelium (RPE) layer and choroid were reduced, and the outer segment of photoreceptors (OS) was thicker in the SHM group compared to the EM and LM/MM groups (all p < 0.05). A longer axial length (AL) was correlated with decreased AULCSF, cone density, and cone spacing (r = -0.800 to 0.752, all p < 0.050). Additionally, decreased CSF was correlated with lower cone density (r = 0.338, p = 0.035).
UNASSIGNED: Decreased contrast sensitivity was observed in patients with SHM and cone density was significantly correlated with reduced AUCSF.
UNASSIGNED: This prospective study comprised 81 subjects, 20 with emmetropia (EM), 26 with low myopia and moderate myopia (LM/MM), and 35 with SHM. The area under the log CSF curve (AULCSF) and the cut-off spatial frequency (Cut-off SF) were employed as measures of CSF. Adaptive optics (AO) was employed to quantify the cone density, spacing, and regularity. The thickness and blood flow of the retinal sublayers were determined from vertical and horizontal optical coherence tomography angiography (OCTA) A-scans. Swept-source optical coherence tomography (SS-OCT) was employed to analyze the choroidal thickness (CT) and choroidal vascularity using a custom algorithm. Differences in the retinal and choroidal parameters, cone distribution, AULCSF, and Cut-off SF were compared among the three groups. Multivariate linear mixed models were used to elucidate the associations between photoreceptor morphological alterations, retinal and choroidal parameters, and AULCSF.
UNASSIGNED: The AULCSF and Cut-off SF were significantly lower in the SHM group compared to the EM and LM groups (p < 0.05). The SHM group had less cone density, larger cone spacing, and lower cone regularity than the EM and LM/MM groups (p < 0.05). Moreover, the thickness of the inner segment of photoreceptors (IS), retinal pigment epithelium (RPE) layer and choroid were reduced, and the outer segment of photoreceptors (OS) was thicker in the SHM group compared to the EM and LM/MM groups (all p < 0.05). A longer axial length (AL) was correlated with decreased AULCSF, cone density, and cone spacing (r = -0.800 to 0.752, all p < 0.050). Additionally, decreased CSF was correlated with lower cone density (r = 0.338, p = 0.035).
UNASSIGNED: Decreased contrast sensitivity was observed in patients with SHM and cone density was significantly correlated with reduced AUCSF.
摘要：
■研究简单高度近视（SHM）的对比敏感度功能（CSF）变化，并评估这些变化与视网膜微观结构早期变化之间的相关性。
■这项前瞻性研究包括81名受试者，20与正视（EM），26患有低度近视和中度近视（LM/MM），和35与SHM。采用logCSF曲线下面积(AULCSF)和截止空间频率(截止SF)作为CSF的量度。自适应光学(AO)用于量化视锥密度，间距,和规律性。通过垂直和水平光学相干断层扫描血管造影（OCTA）A扫描确定视网膜亚层的厚度和血流。采用扫描源光学相干断层扫描（SS-OCT）使用自定义算法分析脉络膜厚度（CT）和脉络膜血管。视网膜和脉络膜参数的差异，圆锥分布，AULCSF,比较三组间的截止SF。多元线性混合模型用于阐明光感受器形态改变之间的关联，视网膜和脉络膜参数，和AULCSF。
■与EM和LM组相比，SHM组的AULCSF和Cut-offSF显着降低（p<0.05）。SHM组的视锥密度较小，较大的锥形间距，锥面规律性低于EM组和LM/MM组(p<0.05)。此外，光感受器内段的厚度(IS)，视网膜色素上皮（RPE）层和脉络膜减少，与EM和LM/MM组相比，SHM组的光感受器（OS）外段较厚（均p<0.05）。轴向长度（AL）较长与AULCSF减少相关，锥密度,和锥体间距(r=-0.800至0.752，所有p<0.050)。此外,CSF降低与锥密度降低相关(r=0.338,p=0.035)。
■在SHM患者中观察到对比敏感度降低，视锥密度与AUCSF降低显著相关。
■这项前瞻性研究包括81名受试者，20与正视（EM），26患有低度近视和中度近视（LM/MM），和35与SHM。采用logCSF曲线下面积(AULCSF)和截止空间频率(截止SF)作为CSF的量度。自适应光学(AO)用于量化视锥密度，间距,和规律性。通过垂直和水平光学相干断层扫描血管造影（OCTA）A扫描确定视网膜亚层的厚度和血流。采用扫描源光学相干断层扫描（SS-OCT）使用自定义算法分析脉络膜厚度（CT）和脉络膜血管。视网膜和脉络膜参数的差异，圆锥分布，AULCSF,比较三组间的截止SF。多元线性混合模型用于阐明光感受器形态改变之间的关联，视网膜和脉络膜参数，和AULCSF。
■与EM和LM组相比，SHM组的AULCSF和Cut-offSF显着降低（p<0.05）。SHM组的视锥密度较小，较大的锥形间距，锥面规律性低于EM组和LM/MM组(p<0.05)。此外，光感受器内段的厚度(IS)，视网膜色素上皮（RPE）层和脉络膜减少，与EM和LM/MM组相比，SHM组的光感受器（OS）外段较厚（均p<0.05）。轴向长度（AL）较长与AULCSF减少相关，锥密度,和锥体间距(r=-0.800至0.752，所有p<0.050)。此外,CSF降低与锥密度降低相关(r=0.338,p=0.035)。
■在SHM患者中观察到对比敏感度降低，视锥密度与AUCSF降低显著相关。
