PDF(Pubmed)
Abstract：
Coronavirus disease 2019 (COVID-19) is a severe and infectious respiratory condition caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This case-control study aimed to evaluate serum levels of various immunological markers in patients with COVID-19 compared to those with bacterial pneumonia and a healthy control group. Serum samples were collected from adult participants across various COVID-19 isolation centers, including Kassala State and Ahmed Gasim Hospital, between April and June 2021. The study included 70 patients diagnosed with COVID-19, 30 with bacterial pneumonia, and 50 healthy controls. Serum levels of C-reactive protein (CRP), complement components C3 and C4, and cytokines IL-8, IL-10, IL-12, TNF-α, and IFN-γ were measured using standard reagent kits. Serum level of CRP was significantly elevated in both bacterial pneumonia and COVID-19 but significantly higher among patients with bacterial pneumonia. C3 and C4 were also increased in both patient groups, with C3 significantly higher in bacterial pneumonia. IL-8, IL-10, IL-12, TNF-α, and IFN-γ were significantly increased in bacterial pneumonia and SARS-Cov-2 compared to healthy controls. However, IFN-γ was significantly increased among patients with COVID-19 than patients with bacterial pneumonia. This study highlights the potential significant impact of COVID-19 on the immunological biomarkers investigated.
摘要：
2019年冠状病毒病（COVID-19）是由严重急性呼吸系统综合症冠状病毒2（SARS-CoV-2）引起的严重的传染性呼吸道疾病。这项病例对照研究旨在评估COVID-19患者与细菌性肺炎患者和健康对照组的血清各种免疫标志物水平。血清样本来自各个COVID-19隔离中心的成年参与者，包括卡萨拉州和艾哈迈德·加西姆医院,2021年4月至6月。该研究包括70例诊断为COVID-19的患者，30例细菌性肺炎，和50个健康对照。血清C反应蛋白(CRP)水平,补体成分C3和C4，以及细胞因子IL-8，IL-10，IL-12，TNF-α，和IFN-γ使用标准试剂盒测量。细菌性肺炎和COVID-19患者血清CRP水平均显著升高，但细菌性肺炎患者血清CRP水平显著升高。C3和C4在两个患者组中也增加，在细菌性肺炎中C3显著增高。IL-8，IL-10，IL-12，TNF-α，与健康对照组相比，细菌性肺炎和SARS-Cov-2中的IFN-γ显着增加。然而,COVID-19患者的IFN-γ明显高于细菌性肺炎患者。这项研究强调了COVID-19对所研究的免疫生物标志物的潜在重大影响。
