PDF(Pubmed)
Abstract：
Neurological immune-related adverse events (irAEs) due to immune checkpoint inhibitors (ICI) are rare complications of immunotherapy, particularly dreadful for patients and clinical teams. Indeed, neurological irAEs are potentially severe and their diagnosis require prompt recognition and treatment. Additionally, the spectrum of neurological irAEs is broad, affecting either neuromuscular junction, peripheral or central nervous system. Here, we described the case of a 55-year man with metastatic melanoma, facing a brutal right peripheral cerebral palsy after his third ipilimumab/nivolumab infusion. After the case presentation, we reviewed the literature about this rare complication of immunotherapy, and described its diagnosis work-up and clinical management.
摘要：
免疫检查点抑制剂（ICI）引起的神经免疫相关不良事件（irAE）是免疫疗法的罕见并发症，对患者和临床团队来说尤其可怕。的确,神经系统性IRAE可能很严重,其诊断需要及时识别和治疗.此外,神经系统IRAE的范围很广，影响任一神经肌肉接头，外周或中枢神经系统。这里,我们描述了一个55岁的转移性黑色素瘤患者，在他的第三次ipilimumab/nivolumab输注后，面临残酷的右周围性脑瘫。在案例介绍之后,我们回顾了关于这种罕见的免疫治疗并发症的文献，并描述了其诊断工作和临床管理。
