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Abstract：
UNASSIGNED: Coronary artery, aortic valve, and descending aorta calcification (CAC, AVC, DAC) are manifestations of atherosclerosis, and cardiac epicardial adipose tissue (EAT) indicates heart adiposity. This study explored the association between cardiac adipose tissue and cardiovascular calcification in participants with long-standing T1D.
UNASSIGNED: EAT and intra-thoracic adipose tissue (IAT) were measured in 100 T1D subjects with cardiac computed tomography (CT) scans in the EDIC study. Volume analysis software was used to measure fat volumes. Spearman correlations were calculated between CAC, AVC, DAC with EAT, and IAT. Associations were evaluated using multiple linear and logistic regression models.
UNASSIGNED: Participants ranged in age from 32 to 57. Mean EAT, and IAT were 38.5 and 50.8 mm3, respectively, and the prevalence of CAC, AVC, and DAC was 43.6 %, 4.7 %, and 26.8 %, respectively. CAC was positively correlated with age (p-value = 0.0001) and EAT (p-value = 0.0149) but not with AVC and DAC; IAT was not associated with calcified lesions. In models adjusted for age and sex, higher levels of EAT and IAT were associated with higher CAC (p-value < 0.0001 for both) and higher AVC (p-values of 0.0111 and 0.0053, respectively), but not with DAC. The associations with CAC remained significant (p-value < 0.0001) after further adjustment for smoking, systolic blood pressure, BMI, and LDL, while the associations with AVC did not remain significant.
UNASSIGNED: In participants with T1D, higher EAT and IAT levels are correlated with higher CAC scores. EAT and IAT were not independently correlated with DAC or AVC.
UNASSIGNED: EAT and intra-thoracic adipose tissue (IAT) were measured in 100 T1D subjects with cardiac computed tomography (CT) scans in the EDIC study. Volume analysis software was used to measure fat volumes. Spearman correlations were calculated between CAC, AVC, DAC with EAT, and IAT. Associations were evaluated using multiple linear and logistic regression models.
UNASSIGNED: Participants ranged in age from 32 to 57. Mean EAT, and IAT were 38.5 and 50.8 mm3, respectively, and the prevalence of CAC, AVC, and DAC was 43.6 %, 4.7 %, and 26.8 %, respectively. CAC was positively correlated with age (p-value = 0.0001) and EAT (p-value = 0.0149) but not with AVC and DAC; IAT was not associated with calcified lesions. In models adjusted for age and sex, higher levels of EAT and IAT were associated with higher CAC (p-value < 0.0001 for both) and higher AVC (p-values of 0.0111 and 0.0053, respectively), but not with DAC. The associations with CAC remained significant (p-value < 0.0001) after further adjustment for smoking, systolic blood pressure, BMI, and LDL, while the associations with AVC did not remain significant.
UNASSIGNED: In participants with T1D, higher EAT and IAT levels are correlated with higher CAC scores. EAT and IAT were not independently correlated with DAC or AVC.
摘要：
■冠状动脉,主动脉瓣,和降主动脉钙化（CAC，AVC,DAC)是动脉粥样硬化的表现，和心外膜脂肪组织（EAT）表明心脏肥胖。这项研究探讨了长期T1D参与者的心脏脂肪组织与心血管钙化之间的关系。
■在EDIC研究中，对100名T1D受试者进行了心脏计算机断层扫描（CT）扫描，测量了EAT和胸内脂肪组织（IAT）。使用体积分析软件测量脂肪体积。计算了CAC之间的Spearman相关性，AVC,带EAT的DAC,和IAT。使用多元线性和逻辑回归模型评估关联。
■参与者的年龄从32岁到57岁不等。平均吃，和IAT分别为38.5和50.8mm3，以及CAC的患病率，AVC,DAC为43.6%，4.7%，和26.8%，分别。CAC与年龄（p值=0.0001）和EAT（p值=0.0149）呈正相关，但与AVC和DAC无关；IAT与钙化病变无关。在根据年龄和性别调整的模型中，较高的EAT和IAT水平与较高的CAC（两者的p值<0.0001）和较高的AVC（p值分别为0.0111和0.0053）相关，但不是DAC。在进一步调整吸烟后，与CAC的关联仍然显着（p值<0.0001），收缩压,BMI,LDL,而与AVC的关联并不显著.
■在T1D参与者中，较高的EAT和IAT水平与较高的CAC评分相关。EAT和IAT与DAC或AVC不独立相关。
■在EDIC研究中，对100名T1D受试者进行了心脏计算机断层扫描（CT）扫描，测量了EAT和胸内脂肪组织（IAT）。使用体积分析软件测量脂肪体积。计算了CAC之间的Spearman相关性，AVC,带EAT的DAC,和IAT。使用多元线性和逻辑回归模型评估关联。
■参与者的年龄从32岁到57岁不等。平均吃，和IAT分别为38.5和50.8mm3，以及CAC的患病率，AVC,DAC为43.6%，4.7%，和26.8%，分别。CAC与年龄（p值=0.0001）和EAT（p值=0.0149）呈正相关，但与AVC和DAC无关；IAT与钙化病变无关。在根据年龄和性别调整的模型中，较高的EAT和IAT水平与较高的CAC（两者的p值<0.0001）和较高的AVC（p值分别为0.0111和0.0053）相关，但不是DAC。在进一步调整吸烟后，与CAC的关联仍然显着（p值<0.0001），收缩压,BMI,LDL,而与AVC的关联并不显著.
■在T1D参与者中，较高的EAT和IAT水平与较高的CAC评分相关。EAT和IAT与DAC或AVC不独立相关。
