Abstract：
Cognitive behavioural therapy (CBT) can effectively treat depression in the general population, but there is a lack of studies evaluating CBT tailored to specific cognitive and communication needs of individuals with post-stroke aphasia. We aimed to evaluate the feasibility and preliminary efficacy of a modified CBT intervention to ameliorate depressive symptoms. An ABA withdrawal/reversal single case design with concurrent multiple baselines (2.5, 4.5, or 6.5 weeks) was repeated across 10 participants (six male, four female) with post-stroke aphasia and self-reported depression. Participants completed 10 individual intervention sessions with a clinical neuropsychologist and a 4-week follow-up. The primary outcome was self-rated depression, and secondary outcomes included observer-rated symptoms of depression and anxiety. Data were analysed visually and statistically controlling for baseline trend. Feasibility was addressed by analysing recruitment and retention rates, treatment adaptations, and fidelity ratings. Three participants self-reported decreased depression levels during the intervention phase, which was sustained for two participants. Four additional participants improved during the follow-up phase. Close others reported sustained improvements in depressive symptoms (six participants) and anxiety symptoms (seven participants). Modified CBT appears feasible and potentially efficacious in reducing depressive symptoms in post-stroke aphasia. A randomized controlled trial is warranted, and should consider additional treatment sessions.
摘要：
认知行为疗法（CBT）可以有效治疗普通人群的抑郁症，但缺乏针对卒中后失语症患者特定认知和沟通需求的CBT评估研究.我们旨在评估改良CBT干预措施改善抑郁症状的可行性和初步疗效。在10名参与者（6名男性，四名女性）患有中风后失语症和自我报告的抑郁症。参与者与临床神经心理学家一起完成了10次个人干预课程，并进行了为期4周的随访。主要结果是自我评估的抑郁症，次要结局包括观察者评估的抑郁和焦虑症状.视觉分析数据并对基线趋势进行统计学控制。通过分析征聘和保留率，解决了可行性，治疗适应，和保真度评级。三名参与者自我报告在干预阶段抑郁水平下降，这对两名参与者来说是持续的。另外四名参与者在后续阶段有所改善。其他人报告抑郁症状（6名参与者）和焦虑症状（7名参与者）持续改善。改良CBT在减少卒中后失语症的抑郁症状方面似乎是可行的，并且可能有效。随机对照试验是有必要的，并应考虑额外的治疗。
