Abstract：
Organophosphorus agents are easily absorbed via respiratory, gastrointestinal, and dermal routes, and inhibit the acetylcholine transferase enzyme (AChE), which is responsible for the majority of toxicity caused by organophosphates in the body. A comprehensive search was conducted across three prominent databases, namely Google Scholar, PubMed, and Science Direct, to identify relevant articles published. The search focused on the keywords \"MgSO4\" or \"magnesium sulfate\" in conjunction with \"organophosphate\" or \"organophosphate poisoning.\" Inhibition of AChE results in the accumulation of acetylcholine (ACh) in synapses and stimulation of cholinergic receptors. Considering that several studies have shown the use of magnesium sulfate (MgSO4) in inhibiting the release of ACh in the central and peripheral sympathetic and parasympathetic synapses, this study was conducted to review the role of MgSO4 in the treatment of OP. The intravenous administration of MgSO4 exhibits favorable tolerability and clinical efficacy in alleviating cardiac toxicity associated with OP exposure.
摘要：
有机磷药物很容易通过呼吸道吸收，胃肠,和真皮路线，并抑制乙酰胆碱转移酶（AChE），这是由体内有机磷引起的大部分毒性的原因。在三个著名的数据库中进行了全面的搜索，即谷歌学者，PubMed,和科学直接，确定发表的相关文章。搜索的重点是关键词“MgSO4”或“硫酸镁”以及“有机磷酸盐”或“有机磷酸盐中毒”。AChE的抑制导致乙酰胆碱（ACh）在突触中的积累和胆碱能受体的刺激。考虑到一些研究表明硫酸镁（MgSO4）在抑制中枢和外周交感神经和副交感神经突触中ACh的释放中的使用，本研究综述了MgSO4在OP治疗中的作用。静脉内施用MgSO4在减轻与OP暴露相关的心脏毒性方面表现出良好的耐受性和临床功效。
