Abstract：
Creatine supplementation has been put forward as a possible aid to cognition, particularly for vegans, vegetarians, the elderly, sleep deprived and hypoxic individuals. However, previous narrative reviews have only provided limited support for these claims. This is despite the fact that research has shown that creatine supplementation can induce increased brain concentrations of creatine, albeit to a limited extent. We carried out a systematic review to examine the current state of affairs. The review supported claims that creatine supplementation can increases brain creatine content but also demonstrated somewhat equivocal results for effects on cognition. It does, however, provide evidence to suggest that more research is required with stressed populations, as supplementation does appear to significantly affect brain content. Issues with research design, especially supplementation regimens, need to be addressed. Future research must include measurements of creatine brain content.
摘要：
补充肌酸已被提出作为一种可能的辅助认知，特别是对于素食主义者来说，素食者,老年人,睡眠不足和缺氧的人。然而,以前的叙述评论仅为这些主张提供了有限的支持。尽管研究表明补充肌酸可以诱导大脑肌酸浓度增加，虽然程度有限。我们进行了系统的审查，以审查目前的状况。该评论支持补充肌酸可以增加脑肌酸含量的说法，但也证明了对认知影响的一些模棱两可的结果。确实如此，然而,提供证据表明需要对压力较大的人群进行更多的研究，因为补充剂似乎会显著影响大脑内容。研究设计的问题，尤其是补充方案，需要解决。未来的研究必须包括肌酸大脑含量的测量。
