PDF(Pubmed)
Abstract：
OBJECTIVE: The diagnosis of progressive fibrosing interstitial lung disease (PF-ILD) using computed tomography (CT) is an important medical practice in respiratory care, and most imaging findings for this disease have been obtained with inspiratory CT. It is possible that some characteristic changes in respiration may be seen in normal and diseased lung in PF-ILD, which may lead to a new understanding of the pathogenesis of interstitial pneumonia, but it has never been examined. In this study, we collected and selected inspiratory and expiratory CT scans performed in pure PF-ILD cases, and evaluated the volumes of diseased and normal lung separately by manual detection and 3-dimensional volumetry to characterize the dynamic features of PF-ILD.
METHODS: Cases were collected retrospectively from a total of 753 inspiratory and expiratory CT scans performed at our hospital over a 3-year period. Sixteen cases of pure PF-ILD, excluding almost all other diseases, were included. We measured their diseased, normal, and the whole lung volumes manually and evaluated the correlation of their values and their relationship with respiratory function tests (FVC, FVC%-predicted, and DLCO%-predicted).
RESULTS: The relative expansion rate of the diseased lung is no less than that of the normal lung. The \"Expansion volume of total lung\" divided by the \"Expansion volume of normal lung\" was found to be significantly associated with DLCO%-predicted abnormalities (p = 0.0073).
CONCLUSIONS: The diseased lung in PF-ILD retained expansion capacity comparable to the normal lung, suggesting a negative impact on respiratory function.
METHODS: Cases were collected retrospectively from a total of 753 inspiratory and expiratory CT scans performed at our hospital over a 3-year period. Sixteen cases of pure PF-ILD, excluding almost all other diseases, were included. We measured their diseased, normal, and the whole lung volumes manually and evaluated the correlation of their values and their relationship with respiratory function tests (FVC, FVC%-predicted, and DLCO%-predicted).
RESULTS: The relative expansion rate of the diseased lung is no less than that of the normal lung. The \"Expansion volume of total lung\" divided by the \"Expansion volume of normal lung\" was found to be significantly associated with DLCO%-predicted abnormalities (p = 0.0073).
CONCLUSIONS: The diseased lung in PF-ILD retained expansion capacity comparable to the normal lung, suggesting a negative impact on respiratory function.
摘要：
目的：使用计算机断层扫描（CT）诊断进行性纤维化间质性肺病（PF-ILD）是呼吸护理的重要医学实践，这种疾病的大多数影像学发现都是通过吸气CT获得的。在PF-ILD中，正常和患病的肺中可能会看到呼吸的一些特征性变化，这可能会导致对间质性肺炎的发病机制有新的认识，但从未检查过。在这项研究中,我们收集并选择了在纯PF-ILD病例中进行的吸气和呼气CT扫描，并通过手动检测和三维容积法分别评估患病和正常肺的体积，以表征PF-ILD的动态特征。
方法：回顾性收集了在我院进行了3年的共753次吸气和呼气CT扫描的病例。16例纯PF-ILD，排除几乎所有其他疾病，包括在内。我们测量了他们的病情，正常,和手动的整个肺容量，并评估其值的相关性及其与呼吸功能测试的关系(FVC，FVC%-预测，和DLCO%-预测)。
结果：病肺的相对扩张率不低于正常肺。发现“总肺膨胀体积”除以“正常肺膨胀体积”与DLCO%预测异常显着相关（p=0.0073）。
结论：PF-ILD中患病的肺保留了与正常肺相当的扩张能力，提示对呼吸功能有负面影响。
方法：回顾性收集了在我院进行了3年的共753次吸气和呼气CT扫描的病例。16例纯PF-ILD，排除几乎所有其他疾病，包括在内。我们测量了他们的病情，正常,和手动的整个肺容量，并评估其值的相关性及其与呼吸功能测试的关系(FVC，FVC%-预测，和DLCO%-预测)。
结果：病肺的相对扩张率不低于正常肺。发现“总肺膨胀体积”除以“正常肺膨胀体积”与DLCO%预测异常显着相关（p=0.0073）。
结论：PF-ILD中患病的肺保留了与正常肺相当的扩张能力，提示对呼吸功能有负面影响。
