Abstract：
BACKGROUND: Historically, neuroblastoma has been diagnosed by surgical open biopsy (SB). In recent decades, core needle biopsy (CNB) has replaced surgical biopsy due to its safe and adequate method of obtaining tissue diagnosis.
OBJECTIVE: Our study aimed to assess the effectiveness of CNB in obtaining tissue diagnosis for neuroblastoma and evaluate its safety profile in terms of post-operative complications, in comparison to SB.
METHODS: A retrospective cohort study, including all patients younger than 18 years who were diagnosed with neuroblastoma from 2012 until 2022 in a single tertiary medical center. Patients\' demographics, tumor size and location, pathological results, and clinical outcomes were collected.
RESULTS: 79 patients were included in our study: 35 biopsies were obtained using image-guided CNB and 44 using SB. Patients\' and tumor characteristics including age, gender, tumor volume, and stage were similar in both groups. The biopsy adequacy rate in the CNB group was 91% and 3 patients in this group underwent repeated biopsy. The safety profile in the CNB group was similar to the SB group.
CONCLUSIONS: CNB is a safe method and should be considered the first choice for obtaining tissue diagnosis when feasible due to its high adequacy in terms of tumor histopathological features.
OBJECTIVE: Our study aimed to assess the effectiveness of CNB in obtaining tissue diagnosis for neuroblastoma and evaluate its safety profile in terms of post-operative complications, in comparison to SB.
METHODS: A retrospective cohort study, including all patients younger than 18 years who were diagnosed with neuroblastoma from 2012 until 2022 in a single tertiary medical center. Patients\' demographics, tumor size and location, pathological results, and clinical outcomes were collected.
RESULTS: 79 patients were included in our study: 35 biopsies were obtained using image-guided CNB and 44 using SB. Patients\' and tumor characteristics including age, gender, tumor volume, and stage were similar in both groups. The biopsy adequacy rate in the CNB group was 91% and 3 patients in this group underwent repeated biopsy. The safety profile in the CNB group was similar to the SB group.
CONCLUSIONS: CNB is a safe method and should be considered the first choice for obtaining tissue diagnosis when feasible due to its high adequacy in terms of tumor histopathological features.
摘要：
背景：历史上，神经母细胞瘤已通过手术开放活检（SB）诊断。近几十年来,芯针活检（CNB）由于其获得组织诊断的安全和适当的方法，已取代了手术活检。
目的：我们的研究旨在评估CNB在神经母细胞瘤的组织诊断中的有效性，并评估其在术后并发症方面的安全性。与SB相比。
方法：一项回顾性队列研究，包括2012年至2022年在一个三级医疗中心诊断为神经母细胞瘤的所有年龄小于18岁的患者.患者人口统计学，肿瘤大小和位置，病理结果,并收集临床结果.
结果：我们的研究包括79例患者：使用图像引导的CNB获得了35例活检，使用SB获得了44例活检。患者和肿瘤特征，包括年龄，性别,肿瘤体积,两组的分期相似。CNB组的活检充分率为91％，该组中有3例患者进行了重复活检。CNB组的安全性与SB组相似。
结论：CNB是一种安全的方法，由于其在肿瘤组织病理学特征方面的高度充分性，在可行的情况下应被视为获得组织诊断的首选。
目的：我们的研究旨在评估CNB在神经母细胞瘤的组织诊断中的有效性，并评估其在术后并发症方面的安全性。与SB相比。
方法：一项回顾性队列研究，包括2012年至2022年在一个三级医疗中心诊断为神经母细胞瘤的所有年龄小于18岁的患者.患者人口统计学，肿瘤大小和位置，病理结果,并收集临床结果.
结果：我们的研究包括79例患者：使用图像引导的CNB获得了35例活检，使用SB获得了44例活检。患者和肿瘤特征，包括年龄，性别,肿瘤体积,两组的分期相似。CNB组的活检充分率为91％，该组中有3例患者进行了重复活检。CNB组的安全性与SB组相似。
结论：CNB是一种安全的方法，由于其在肿瘤组织病理学特征方面的高度充分性，在可行的情况下应被视为获得组织诊断的首选。
