Abstract：
As one of the earliest discovered lncRNA molecules, lncRNA H19 is usually expressed in large quantities during embryonic development and is involved in cell differentiation and tissue formation. In recent years, the role of lncRNA H19 in tumors has been gradually recognized. Increasing evidence suggests that its aberrant expression is closely related to cancer development. LncRNA H19 as an oncogene not only promotes the growth, proliferation, invasion and metastasis of many tumors, but also develops resistance to treatment, affecting patients\' prognosis and survival. Therefore, in this review, we summarise the extensive research on the involvement of lncRNA H19 in tumor progression and discuss how lncRNA H19, as a key target gene, affects tumor sensitivity to radiotherapy, chemotherapy and immunotherapy by participating in multiple cellular processes and regulating multiple signaling pathways, which provides a promising prospect for further research into the treatment of cancer.
摘要：
作为最早发现的lncRNA分子之一，lncRNAH19通常在胚胎发育过程中大量表达，并参与细胞分化和组织形成。近年来,lncRNAH19在肿瘤中的作用已被逐渐认识到。越来越多的证据表明，其异常表达与癌症的发展密切相关。LncRNAH19作为癌基因不仅促进生长，扩散,许多肿瘤的侵袭和转移，还会对治疗产生抗药性，影响患者预后和生存。因此,在这次审查中,我们总结了lncRNAH19参与肿瘤进展的广泛研究，并讨论了lncRNAH19作为关键靶基因，影响肿瘤对放疗的敏感性，化疗和免疫治疗通过参与多个细胞过程和调节多个信号通路，这为进一步研究癌症治疗提供了广阔的前景。
