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Abstract：
This work proposes the use of multi-criteria decision analysis (MCDA) to select a more environmentally friendly analytical procedure. TOPSIS, which stands for Technique for Order of Preference by Similarity to Ideal Solution, is an example of a MCDA method that may be used to rank or select best alternative based on various criteria. Thirteen analytical procedures were used in this study as TOPSIS input choices for mifepristone determination in water samples. The input data, which consisted of these choices, was described using assessment criteria based on 12 principles of green analytical chemistry (GAC). Based on the objective mean weighting (MW), the weights for each criterion were assigned equally. The most preferred analytical method according to the ranking was solid phase extraction with micellar electrokinetic chromatography (SPE-MEKC), while solid phase extraction combined with ultra-high performance liquid chromatography tandem mass spectrometry (SPE-UHPLC-MS/MS) was ranked last. TOPSIS ranking results were also compared to the green metrics NEMI, Eco-Scale, GAPI, AGREE, and AGREEprep that were used to assess the greenness of thirteen analytical methods for mifepristone determination. The results demonstrated that only the AGREE metric tool correlated with TOPSIS; however, there was no correlation with other metric tools. The analysis results suggest that TOPSIS is a very useful tool for ranking or selecting the analytical procedure in terms of its greenness and that it can be easily integrated with other green metrics tools for method greenness assessment.
摘要：
这项工作提出了使用多准则决策分析（MCDA）来选择更环保的分析程序。TOPSIS,代表与理想解决方案相似的偏好顺序技术，是可以用于基于各种标准对最佳备选方案进行排序或选择的MCDA方法的示例。本研究使用了13种分析程序作为TOPSIS输入选择，用于测定水样中米非司酮。输入数据，其中包括这些选择，使用基于12项绿色分析化学(GAC)原理的评估标准进行了描述。根据客观平均权重(MW)，每个标准的权重分配相等.根据排序，最优选的分析方法是使用胶束电动色谱（SPE-MEKC）的固相萃取，固相萃取联合超高效液相色谱-串联质谱(SPE-UHPLC-MS/MS)技术排名最后。TOPSIS排名结果也与绿色指标NEMI进行了比较，生态规模，GAPI,同意,和AGREEPrep用于评估米非司酮测定的13种分析方法的绿色性。结果表明，只有AGREE度量工具与TOPSIS相关；然而，与其他度量工具没有相关性。分析结果表明，TOPSIS是根据绿色度对分析程序进行排名或选择的非常有用的工具，并且可以轻松地与其他绿色度量工具集成以进行方法绿色度评估。
