PDF(Pubmed)
Abstract：
As a crucial component of the male reproductive system, the epididymis plays multiple roles, including sperm storage and secretion of nutritive fluids for sperm development and maturation. The acquisition of fertilization capacity by sperm occurs during their transport through the epididymis. Compared with the testis, little has been realized about the importance of the epididymis. However, with the development of molecular biology and single-cell sequencing technology, the importance of the epididymis for male fertility should be reconsidered. Recent studies have revealed that different regions of the epididymis exhibit distinct functions and cell type compositions, which are likely determined by variations in gene expression patterns. In this research, we primarily focused on elucidating the cellular composition and region-specific gene expression patterns within different segments of the epididymis and provided detailed insights into epididymal function in male fertility.
摘要：
作为男性生殖系统的重要组成部分，附睾扮演多重角色,包括精子储存和分泌营养液，用于精子发育和成熟。精子在通过附睾运输过程中获得受精能力。与睾丸相比，人们很少意识到附睾的重要性。然而,随着分子生物学和单细胞测序技术的发展,应重新考虑附睾对男性生育能力的重要性。最近的研究表明，附睾的不同区域表现出不同的功能和细胞类型组成，这可能是由基因表达模式的变化决定的。在这项研究中,我们主要集中在阐明附睾不同部分的细胞组成和区域特异性基因表达模式，并提供了有关男性生育力中附睾功能的详细见解。
