PDF(Pubmed)
Abstract：
Diffuse large B cell lymphoma (DLBCL) is one of the most prevalent subtypes of non-Hodgkin lymphoma (NHL) and is known for commonly infiltrating extra-nodal sites. The involvement of the bone marrow by lymphoma cells significantly impacts the staging, treatment, and prognosis among the extra-nodal sites in DLBCL. Bone marrow biopsy has been considered the standard diagnostic procedure for detecting bone marrow involvement. However, advancements in imaging techniques, such as positron emission tomography-computed tomography (PET-CT), have shown an improved ability to detect bone marrow involvement, making the need for bone marrow biopsy debatable. This review aims to emphasize the importance of bone marrow evaluation in adult patients newly diagnosed with DLBCL and suggest an optimal diagnostic approach to identify bone marrow involvement in these patients.
摘要：
弥漫性大B细胞淋巴瘤（DLBCL）是非霍奇金淋巴瘤（NHL）最常见的亚型之一，通常以浸润结外位点而闻名。淋巴瘤细胞对骨髓的参与显着影响分期，治疗,和DLBCL结外位点的预后。骨髓活检已被认为是检测骨髓受累的标准诊断程序。然而,成像技术的进步，如正电子发射断层扫描-计算机断层扫描(PET-CT)，已经显示出检测骨髓受累的能力得到了改善，骨髓活检的需要值得商榷。这篇综述旨在强调骨髓评估在新诊断为DLBCL的成年患者中的重要性，并提出一种最佳的诊断方法来识别这些患者的骨髓受累。
