PDF(Pubmed)
Abstract：
UNASSIGNED: Dermatomyositis (DM), sometimes referred to as inflammatory and degenerative changes in the skin and muscles, is a rare autoimmune disorder. DM is distinguished by myopathic disease, symmetrical proximal muscle weakness, and increased creatine kinase (CK).
UNASSIGNED: A 30-year-old-female presented to the department of dermatology with a history of chronic right hand pain spreading to the shoulder, severe tachycardia, and dyspenia that increased during routine tasks like using the bathroom. What makes this case unique is that the CPK developed without doubling, and the final concentration was 207 ng/ml. Other common clinical symptoms include amyopathic/hypomyopathic muscle involvement and DM-specific rash (Gottron\'s papules, heliotrope rash), and these manifestations were in our patients. Sun protection, topical treatment with corticosteroids and/or calcineurin inhibitors, and systemic medication should be utilized for all individuals with nonvasculopathic disease. In our case, the patient stopped using azathioprine and began taking methotrexate.
UNASSIGNED: Sun protection, topical therapy with corticosteroids and/or calcineurin inhibitors, and systemic medication should be utilized in layers for all individuals with nonvasculopathic illnesses. Mycophenolat Mofetil is beneficial in treating refractory illnesses as well as individuals with interstitial lung disease or substantial skin disease.
UNASSIGNED: Even if test findings are not conclusive, dermatomyositis should always be considered when muscular weakness manifests. It\'s important to distinguish the disorder from connective tissue diseases like lupus erythematosus. In fact, to correctly diagnose DM, if there are any doubts, a muscle biopsy is required.
UNASSIGNED: A 30-year-old-female presented to the department of dermatology with a history of chronic right hand pain spreading to the shoulder, severe tachycardia, and dyspenia that increased during routine tasks like using the bathroom. What makes this case unique is that the CPK developed without doubling, and the final concentration was 207 ng/ml. Other common clinical symptoms include amyopathic/hypomyopathic muscle involvement and DM-specific rash (Gottron\'s papules, heliotrope rash), and these manifestations were in our patients. Sun protection, topical treatment with corticosteroids and/or calcineurin inhibitors, and systemic medication should be utilized for all individuals with nonvasculopathic disease. In our case, the patient stopped using azathioprine and began taking methotrexate.
UNASSIGNED: Sun protection, topical therapy with corticosteroids and/or calcineurin inhibitors, and systemic medication should be utilized in layers for all individuals with nonvasculopathic illnesses. Mycophenolat Mofetil is beneficial in treating refractory illnesses as well as individuals with interstitial lung disease or substantial skin disease.
UNASSIGNED: Even if test findings are not conclusive, dermatomyositis should always be considered when muscular weakness manifests. It\'s important to distinguish the disorder from connective tissue diseases like lupus erythematosus. In fact, to correctly diagnose DM, if there are any doubts, a muscle biopsy is required.
摘要：
■皮肌炎（DM），有时被称为皮肤和肌肉的炎症和退行性变化，是一种罕见的自身免疫性疾病.DM以肌病性疾病为特征，对称近端肌无力，肌酸激酶（CK）增加。
■一位30岁的女性出现在皮肤科，有慢性右手疼痛扩散到肩部的病史，严重的心动过速,和在使用浴室等日常任务中增加的困难。这种情况的独特之处在于CPK的发展没有加倍，最终浓度为207ng/ml。其他常见的临床症状包括肌病性/肌病性肌肉受累和DM特异性皮疹（Gottron’s丘疹，天麻皮疹)，这些表现在我们的病人身上。防晒,用皮质类固醇和/或钙调磷酸酶抑制剂局部治疗，所有非血管性疾病患者均应使用全身性药物治疗。在我们的案例中,患者停止使用硫唑嘌呤,开始服用甲氨蝶呤.
■防晒,使用皮质类固醇和/或钙调磷酸酶抑制剂的局部治疗，对于所有非血管病理性疾病的患者，应分层使用全身性药物。霉酚酸酯有益于治疗难治性疾病以及患有间质性肺病或实质性皮肤病的个体。
■即使测试结果没有定论，当出现肌肉无力时，应始终考虑皮肌炎。区分疾病和结缔组织疾病如红斑狼疮是很重要的。事实上,为了正确诊断DM，如果有任何疑问，需要进行肌肉活检。
■一位30岁的女性出现在皮肤科，有慢性右手疼痛扩散到肩部的病史，严重的心动过速,和在使用浴室等日常任务中增加的困难。这种情况的独特之处在于CPK的发展没有加倍，最终浓度为207ng/ml。其他常见的临床症状包括肌病性/肌病性肌肉受累和DM特异性皮疹（Gottron’s丘疹，天麻皮疹)，这些表现在我们的病人身上。防晒,用皮质类固醇和/或钙调磷酸酶抑制剂局部治疗，所有非血管性疾病患者均应使用全身性药物治疗。在我们的案例中,患者停止使用硫唑嘌呤,开始服用甲氨蝶呤.
■防晒,使用皮质类固醇和/或钙调磷酸酶抑制剂的局部治疗，对于所有非血管病理性疾病的患者，应分层使用全身性药物。霉酚酸酯有益于治疗难治性疾病以及患有间质性肺病或实质性皮肤病的个体。
■即使测试结果没有定论，当出现肌肉无力时，应始终考虑皮肌炎。区分疾病和结缔组织疾病如红斑狼疮是很重要的。事实上,为了正确诊断DM，如果有任何疑问，需要进行肌肉活检。
