PDF(Pubmed)
Abstract：
UNASSIGNED: Guillain-Barre syndrome (GBS) has been found to have some interesting association with vaccinations. This paper mainly focuses on exploring different associations between COVID-19 vaccination and GBS.
UNASSIGNED: Electronic databases such as PubMed, Google Scholar, Cochrane, and Embase were searched using MESH terms for case reports published till 1 August 2023 from which 70 case reports were documented involving 103 individuals from 23 different countries.
UNASSIGNED: The case reports were from a wide range of individuals aged from 13 to 87 years with an average age of 53±20 interquartile range years along with male predominance. The average time between receiving the vaccine and the onset of symptoms was 13.08±2.14 days. Prominent clinical features included back pain, facial diplegia, weakness, and paraesthesia whereas the main diagnostic studies were cerebrospinal fluid (CSF) analysis and electromagnetic studies. The principal diagnostic clue was albumin-cytological dissociation in CSF while being negative for anti-ganglioside antibodies or SARS-CoV-2. Available treatment options consisted of intravenous immunoglobulin and Plasmapheresis. Patients with comorbidities such as diabetes mellitus, hypertension, dyslipidemia, permanent atrial fibrillation, hypothyroidism, Hashimoto\'s thyroiditis, Chronic Obstructive Pulmonary Disease, asthma, osteoporosis, migraine, rheumatoid arthritis, osteoarthritis, ulcerative colitis, coeliac disease, seizures, bipolar disorder, endometriosis, multiple sclerosis, bell\'s palsy, squamous cell carcinoma, prostate cancer were included in our study.
UNASSIGNED: Overall, this review evaluated innovative and clinically relevant associations between COVID-19 vaccination and GBS. Understanding of this uncommon potential side effect of COVID-19 vaccination is crucial for prompt diagnosis and appropriate treatment. Importantly, GBS should not be considered a contraindication to vaccination. This underscores the importance of ongoing research to enhance the safety and efficacy of COVID-19 vaccination efforts.
UNASSIGNED: Electronic databases such as PubMed, Google Scholar, Cochrane, and Embase were searched using MESH terms for case reports published till 1 August 2023 from which 70 case reports were documented involving 103 individuals from 23 different countries.
UNASSIGNED: The case reports were from a wide range of individuals aged from 13 to 87 years with an average age of 53±20 interquartile range years along with male predominance. The average time between receiving the vaccine and the onset of symptoms was 13.08±2.14 days. Prominent clinical features included back pain, facial diplegia, weakness, and paraesthesia whereas the main diagnostic studies were cerebrospinal fluid (CSF) analysis and electromagnetic studies. The principal diagnostic clue was albumin-cytological dissociation in CSF while being negative for anti-ganglioside antibodies or SARS-CoV-2. Available treatment options consisted of intravenous immunoglobulin and Plasmapheresis. Patients with comorbidities such as diabetes mellitus, hypertension, dyslipidemia, permanent atrial fibrillation, hypothyroidism, Hashimoto\'s thyroiditis, Chronic Obstructive Pulmonary Disease, asthma, osteoporosis, migraine, rheumatoid arthritis, osteoarthritis, ulcerative colitis, coeliac disease, seizures, bipolar disorder, endometriosis, multiple sclerosis, bell\'s palsy, squamous cell carcinoma, prostate cancer were included in our study.
UNASSIGNED: Overall, this review evaluated innovative and clinically relevant associations between COVID-19 vaccination and GBS. Understanding of this uncommon potential side effect of COVID-19 vaccination is crucial for prompt diagnosis and appropriate treatment. Importantly, GBS should not be considered a contraindication to vaccination. This underscores the importance of ongoing research to enhance the safety and efficacy of COVID-19 vaccination efforts.
摘要：
■已发现格林-巴利综合征（GBS）与疫苗接种有一些有趣的关联。本文主要探讨COVID-19疫苗接种与GBS之间的不同关联。
■电子数据库，如PubMed，谷歌学者，科克伦,和Embase使用MESH术语检索了截至2023年8月1日发布的病例报告,其中记录了70例病例报告,涉及来自23个不同国家的103人.
■病例报告来自13至87岁的广泛个体，平均年龄为53±20四分位龄，男性占优势。接种疫苗和症状发作之间的平均时间为13.08±2.14天。突出的临床特征包括背痛，面部瘫痪,弱点,和感觉异常，而主要的诊断研究是脑脊液（CSF）分析和电磁研究。主要诊断线索是脑脊液中白蛋白细胞学解离，同时抗神经节苷脂抗体或SARS-CoV-2阴性。可用的治疗选择包括静脉注射免疫球蛋白和血浆置换。患有糖尿病等合并症的患者，高血压,血脂异常,永久性心房颤动,甲状腺功能减退,桥本甲状腺炎,慢性阻塞性肺疾病,哮喘,骨质疏松,偏头痛,类风湿性关节炎,骨关节炎,溃疡性结肠炎,乳糜泻,癫痫发作,双相情感障碍,子宫内膜异位症,多发性硬化症,贝尔麻痹,鳞状细胞癌,前列腺癌被纳入我们的研究.
■总的来说，这篇综述评估了COVID-19疫苗接种与GBS之间的创新性和临床相关关联.了解COVID-19疫苗接种的这种罕见的潜在副作用对于及时诊断和适当治疗至关重要。重要的是,GBS不应被视为疫苗接种的禁忌症。这强调了正在进行的研究以提高COVID-19疫苗接种工作的安全性和有效性的重要性。
■电子数据库，如PubMed，谷歌学者，科克伦,和Embase使用MESH术语检索了截至2023年8月1日发布的病例报告,其中记录了70例病例报告,涉及来自23个不同国家的103人.
■病例报告来自13至87岁的广泛个体，平均年龄为53±20四分位龄，男性占优势。接种疫苗和症状发作之间的平均时间为13.08±2.14天。突出的临床特征包括背痛，面部瘫痪,弱点,和感觉异常，而主要的诊断研究是脑脊液（CSF）分析和电磁研究。主要诊断线索是脑脊液中白蛋白细胞学解离，同时抗神经节苷脂抗体或SARS-CoV-2阴性。可用的治疗选择包括静脉注射免疫球蛋白和血浆置换。患有糖尿病等合并症的患者，高血压,血脂异常,永久性心房颤动,甲状腺功能减退,桥本甲状腺炎,慢性阻塞性肺疾病,哮喘,骨质疏松,偏头痛,类风湿性关节炎,骨关节炎,溃疡性结肠炎,乳糜泻,癫痫发作,双相情感障碍,子宫内膜异位症,多发性硬化症,贝尔麻痹,鳞状细胞癌,前列腺癌被纳入我们的研究.
■总的来说，这篇综述评估了COVID-19疫苗接种与GBS之间的创新性和临床相关关联.了解COVID-19疫苗接种的这种罕见的潜在副作用对于及时诊断和适当治疗至关重要。重要的是,GBS不应被视为疫苗接种的禁忌症。这强调了正在进行的研究以提高COVID-19疫苗接种工作的安全性和有效性的重要性。
