PDF(Pubmed)
Abstract：
BACKGROUND: Prolonged donor hepatectomy time may be implicated in early and late complications of liver transplantation.
OBJECTIVE: To evaluate the impact of donor hepatectomy time on outcomes of liver transplant recipients, mainly early allograft dysfunction.
METHODS: This multicenter retrospective study included brain-dead donors and adult liver graft recipients. Donor-recipient matching was obtained through a crossover list. Clinical and laboratory data were recorded for both donors and recipients. Donor hepatectomy, cold ischemia, and warm ischemia times were recorded. Primary outcome was early allograft dysfunction. Secondary outcomes included need for retransplantation, length of intensive care unit and hospital stay, and patient and graft survival at 12 months.
RESULTS: From January 2019 to December 2021, a total of 243 patients underwent a liver transplant from a brain-dead donor. Of these, 57 (25%) developed early allograft dysfunction. The median donor hepatectomy time was 29 (23-40) min. Patients with early allograft dysfunction had a median hepatectomy time of 25 (22-38) min, whereas those without it had a median time of 30 (24-40) min (P = 0.126).
CONCLUSIONS: Donor hepatectomy time was not associated with early allograft dysfunction, graft survival, or patient survival following liver transplantation.
OBJECTIVE: To evaluate the impact of donor hepatectomy time on outcomes of liver transplant recipients, mainly early allograft dysfunction.
METHODS: This multicenter retrospective study included brain-dead donors and adult liver graft recipients. Donor-recipient matching was obtained through a crossover list. Clinical and laboratory data were recorded for both donors and recipients. Donor hepatectomy, cold ischemia, and warm ischemia times were recorded. Primary outcome was early allograft dysfunction. Secondary outcomes included need for retransplantation, length of intensive care unit and hospital stay, and patient and graft survival at 12 months.
RESULTS: From January 2019 to December 2021, a total of 243 patients underwent a liver transplant from a brain-dead donor. Of these, 57 (25%) developed early allograft dysfunction. The median donor hepatectomy time was 29 (23-40) min. Patients with early allograft dysfunction had a median hepatectomy time of 25 (22-38) min, whereas those without it had a median time of 30 (24-40) min (P = 0.126).
CONCLUSIONS: Donor hepatectomy time was not associated with early allograft dysfunction, graft survival, or patient survival following liver transplantation.
摘要：
背景：延长供肝切除时间可能与肝移植的早期和晚期并发症有关。
目的：评估供肝切除时间对肝移植受者预后的影响，主要是早期同种异体移植功能障碍。
方法：这项多中心回顾性研究包括脑死亡供体和成人肝移植受体。通过交叉列表获得供体-受体匹配。记录供体和受体的临床和实验室数据。供体肝切除术,冷缺血，记录热缺血时间。主要结果是早期同种异体移植功能障碍。次要结果包括需要再次移植，重症监护室的长度和住院时间，以及患者和移植物在12个月时的存活率。
结果：从2019年1月到2021年12月，共有243名患者接受了脑死亡供体的肝移植。其中,57（25％）发生了早期同种异体移植功能障碍。供体肝切除术的中位时间为29（23-40）min。早期同种异体移植功能障碍患者的中位肝切除时间为25（22-38）min，而那些没有它的中位时间为30（24-40）min（P=0.126）。
结论：供肝切除时间与早期同种异体移植功能障碍无关，移植物存活，或肝移植后患者的存活率。
目的：评估供肝切除时间对肝移植受者预后的影响，主要是早期同种异体移植功能障碍。
方法：这项多中心回顾性研究包括脑死亡供体和成人肝移植受体。通过交叉列表获得供体-受体匹配。记录供体和受体的临床和实验室数据。供体肝切除术,冷缺血，记录热缺血时间。主要结果是早期同种异体移植功能障碍。次要结果包括需要再次移植，重症监护室的长度和住院时间，以及患者和移植物在12个月时的存活率。
结果：从2019年1月到2021年12月，共有243名患者接受了脑死亡供体的肝移植。其中,57（25％）发生了早期同种异体移植功能障碍。供体肝切除术的中位时间为29（23-40）min。早期同种异体移植功能障碍患者的中位肝切除时间为25（22-38）min，而那些没有它的中位时间为30（24-40）min（P=0.126）。
结论：供肝切除时间与早期同种异体移植功能障碍无关，移植物存活，或肝移植后患者的存活率。
