PDF(Pubmed)
Abstract：
Diabetic gastroparesis (DGP) is a common complication of diabetes mellitus, marked by gastrointestinal motility disorder, a delayed gastric emptying present in the absence of mechanical obstruction. Clinical manifestations include postprandial fullness and epigastric discomfort, bloating, nausea, and vomiting. DGP may significantly affect the quality of life and productivity of patients. Research on the relationship between gastrointestinal dynamics and DGP has received much attention because of the increasing prevalence of DGP. Gastrointestinal motility disorders are closely related to a variety of factors including the absence and destruction of interstitial cells of Cajal, abnormalities in the neuro-endocrine system and hormone levels. Therefore, this study will review recent literature on the mechanisms of DGP and gastrointestinal motility disorders as well as the development of prokinetic treatment of gastrointestinal motility disorders in order to give future research directions and identify treatment strategies for DGP.
摘要：
糖尿病性胃轻瘫(DGP)是糖尿病的常见并发症,以胃肠动力障碍为标志，在没有机械性梗阻的情况下出现胃排空延迟。临床表现包括餐后饱胀和上腹部不适,腹胀,恶心,和呕吐。DGP可能会显著影响患者的生活质量和生产力。随着DGP患病率的增加,胃肠动力学与DGP关系的研究备受关注。胃肠动力障碍与多种因素密切相关，包括Cajal间质细胞的缺失和破坏，神经内分泌系统和激素水平异常。因此,本研究将回顾有关DGP和胃肠动力障碍的机制以及胃肠动力障碍的促动力治疗进展的最新文献，以便为未来的研究方向和确定DGP的治疗策略。
