PDF(Pubmed)
Abstract：
BACKGROUND: Skin barrier function assessment is commonly done by measuring transepidermal water loss (TEWL). An important limitation of this method is the influence of intrinsic and extrinsic factors. Electrical impedance spectroscopy (EIS) is a lesser-established method for skin barrier function assessment. Some influential factors have been described, but no guidelines exist regarding the standardization of these measurements.
OBJECTIVE: To evaluate the effect size of daily routine activities on TEWL and EIS, as well as their correlation with age and anatomical differences.
METHODS: Healthy participants (n=31) were stratified into three age groups (18-29, 30-49, and ≥50 years). In a climate-controlled room, EIS and TEWL measurements were performed on the left and right volar forearm and abdomen.
RESULTS: Body cream application decreased TEWL and EIS values after 15 and 90 minutes. Skin washing decreased TEWL for 15 minutes and EIS values for at least 90 minutes. TEWL was increased 5 minutes after moderate to intense exercise. Coffee intake increased TEWL on the abdomen after 60 minutes. TEWL and EIS values did not correlate with participants\' age and no anatomical differences were observed. No correlation was observed between TEWL and EIS.
CONCLUSIONS: Body cream application and skin washing should be avoided at least 90 minutes prior to measurements of TEWL and EIS. Exercise and coffee intake should also be avoided prior to TEWL measurements. EIS may be a promising tool for skin barrier function assessment as it is less affected by daily routine activities than TEWL.
OBJECTIVE: To evaluate the effect size of daily routine activities on TEWL and EIS, as well as their correlation with age and anatomical differences.
METHODS: Healthy participants (n=31) were stratified into three age groups (18-29, 30-49, and ≥50 years). In a climate-controlled room, EIS and TEWL measurements were performed on the left and right volar forearm and abdomen.
RESULTS: Body cream application decreased TEWL and EIS values after 15 and 90 minutes. Skin washing decreased TEWL for 15 minutes and EIS values for at least 90 minutes. TEWL was increased 5 minutes after moderate to intense exercise. Coffee intake increased TEWL on the abdomen after 60 minutes. TEWL and EIS values did not correlate with participants\' age and no anatomical differences were observed. No correlation was observed between TEWL and EIS.
CONCLUSIONS: Body cream application and skin washing should be avoided at least 90 minutes prior to measurements of TEWL and EIS. Exercise and coffee intake should also be avoided prior to TEWL measurements. EIS may be a promising tool for skin barrier function assessment as it is less affected by daily routine activities than TEWL.
摘要：
背景：皮肤屏障功能评估通常通过测量经表皮水分流失（TEWL）来进行。这种方法的一个重要限制是内在和外在因素的影响。电阻抗谱（EIS）是一种较少建立的皮肤屏障功能评估方法。描述了一些影响因素，但是没有关于这些测量标准化的指南。
目的：为了评估日常活动对TEWL和EIS的影响大小，以及它们与年龄和解剖学差异的相关性。
方法：健康参与者（n=31）被分为三个年龄组（18-29岁、30-49岁和≥50岁）。在气候控制的房间里，在左，右前臂和腹部进行EIS和TEWL测量。
结果：Body乳膏的应用在15和90分钟后降低了TEWL和EIS值。皮肤洗涤降低TEWL持续15分钟并且EIS值持续至少90分钟。TEWL在中度至剧烈运动后5分钟增加。60分钟后，咖啡摄入量增加了腹部的TEWL。TEWL和EIS值与参与者年龄无关，也未观察到解剖学差异。在TEWL和EIS之间没有观察到相关性。
结论：在测量TEWL和EIS之前至少90分钟，应避免使用身体乳膏和皮肤清洗。在TEWL测量之前，还应避免运动和咖啡摄入。EIS可能是评估皮肤屏障功能的有前途的工具，因为与TEWL相比，EIS受日常活动的影响较小。
目的：为了评估日常活动对TEWL和EIS的影响大小，以及它们与年龄和解剖学差异的相关性。
方法：健康参与者（n=31）被分为三个年龄组（18-29岁、30-49岁和≥50岁）。在气候控制的房间里，在左，右前臂和腹部进行EIS和TEWL测量。
结果：Body乳膏的应用在15和90分钟后降低了TEWL和EIS值。皮肤洗涤降低TEWL持续15分钟并且EIS值持续至少90分钟。TEWL在中度至剧烈运动后5分钟增加。60分钟后，咖啡摄入量增加了腹部的TEWL。TEWL和EIS值与参与者年龄无关，也未观察到解剖学差异。在TEWL和EIS之间没有观察到相关性。
结论：在测量TEWL和EIS之前至少90分钟，应避免使用身体乳膏和皮肤清洗。在TEWL测量之前，还应避免运动和咖啡摄入。EIS可能是评估皮肤屏障功能的有前途的工具，因为与TEWL相比，EIS受日常活动的影响较小。
