Abstract:
The clinical presentation of eosinophilic gastrointestinal diseases beyond eosinophilic esophagitis (non-EoE EGIDs) varies depending on the gastrointestinal segments affected by the eosinophilic inflammation, the extent of eosinophilic inflammation within the gastrointestinal tract and its depth through the bowel wall. Non-EoE EGIDs with mucosal involvement tend to present with diarrhea, malabsorption, and sometimes bleeding, those with muscular involvement may present with symptoms of obstruction or pseudo-obstruction, intussusception, and even perforation, whereas those with serosal involvement may present with eosinophilic ascites. Here we describe the differences in symptoms experienced by children with non-EoE EGIDs with varying degrees of eosinophilic inflammation through the bowel wall.
摘要:
除嗜酸性粒细胞性食管炎(非EoEEGIDs)外,嗜酸性粒细胞性胃肠道疾病的临床表现因受嗜酸性粒细胞性炎症影响的胃肠道节段而异。胃肠道内嗜酸性粒细胞炎症的程度及其通过肠壁的深度。粘膜受累的非EoEEGIDs倾向于表现为腹泻,吸收不良,有时流血,那些肌肉受累的人可能会出现梗阻或假性梗阻的症状,肠套叠,甚至穿孔,而浆膜受累的患者可能存在嗜酸性粒细胞性腹水。在这里,我们描述了非EoEEGID儿童经历的症状差异,这些儿童具有不同程度的嗜酸性粒细胞性炎症通过肠壁。