Abstract：
Cyclodextrin-based metal-organic framework (CD-MOF) has been widely used in various delivery systems due to its excellent edibility and high drug loading capacity. However, its typically bulky size and high brittleness in aqueous solutions pose significant challenges for practical applications. Here, we proposed an ultrasonic-assisted method for rapid synthesis of uniformly-sized nanoscale CD-MOF, followed by its hydrophobic modification through ester bond cross-linking (Nano-CMOF). Proper ultrasound treatment effectively reduced particle size to nanoscale (393.14 nm). Notably, carbonate ester cross-linking method significantly improved water stability without altering its cubic shape and high porosity (1.3 cm3/g), resulting in a retention rate exceeding 90% in various media. Furthermore, the loading of quercetin did not disrupt cubic structure and showcased remarkable storage stability. Nano-CMOF achieved controlled release of quercetin in both aqueous environments and digestion. Additionally, Nano-CMOF demonstrated exceptional antioxidant (free radical scavenging 82.27%) and biocompatibility, indicating its significant potential as novel nutritional delivery systems in food and biomedical fields.
摘要：
基于环糊精的金属有机骨架（CD-MOF）由于其优异的可食性和高的载药量而被广泛用于各种递送系统。然而,其通常庞大的尺寸和在水溶液中的高脆性对实际应用提出了重大挑战。这里,我们提出了一种超声辅助快速合成均匀尺寸纳米级CD-MOF的方法，然后通过酯键交联（Nano-CMOF）进行疏水改性。适当的超声处理有效地将颗粒尺寸减小到纳米级(393.14nm)。值得注意的是,碳酸酯交联法显著提高了水稳定性，而不改变其立方体形状和高孔隙率(1.3cm3/g)，导致在各种介质中的保留率超过90%。此外，槲皮素的负载没有破坏立方结构，并显示出显着的储存稳定性。Nano-CMOF在水环境和消化中均可实现槲皮素的控制释放。此外,Nano-CMOF表现出优异的抗氧化剂（自由基清除82.27%）和生物相容性，表明其作为食品和生物医学领域新型营养输送系统的巨大潜力。
