METHODS: The study population consists of 138 patients with schizophrenia-spectrum disorder, of whom 54 were drug-naïve, compared to 317 general population controls. The potential confounders age, gender, smoking and body mass index (BMI) were adjusted for in linear regression models.
RESULTS: The total patient group showed significantly higher levels of ICAM-1 (p < 0.001) and VCAM-1 (p < 0.001) compared to controls. Previously medicated patients showed higher ICAM-1 levels compared to drug-naïve patients (p = 0.042) and controls (p < 0.001), and elevated VCAM-1 levels compared to controls (p < 0.001). Drug-naive patients had elevated levels of VCAM-1 (p = 0.031) compared to controls.
CONCLUSIONS: In our study, patients with schizophrenia - including the drug-naïve - have higher levels of soluble CAMs compared to healthy controls. These findings suggest activation of the endothelial system as in inflammation.
方法:研究人群包括138名精神分裂症谱系障碍患者,其中54人是吸毒,与317个一般人群对照相比。潜在的混杂因素年龄,性别,在线性回归模型中校正了吸烟和体重指数(BMI).
结果:与对照组相比,患者组的ICAM-1(p<0.001)和VCAM-1(p<0.001)水平明显更高。与未服药的患者(p=0.042)和对照组(p<0.001)相比,以前服药的患者表现出更高的ICAM-1水平,与对照组相比,VCAM-1水平升高(p<0.001)。与对照组相比,未接受药物治疗的患者的VCAM-1水平升高(p=0.031)。
结论:在我们的研究中,与健康对照组相比,精神分裂症患者-包括初治药物-具有更高水平的可溶性CAM。这些发现表明在炎症中激活内皮系统。