Abstract：
BACKGROUND: Endothelial inflammation may be involved in the pathogenesis of schizophrenia, and cellular adhesion molecules (CAMs) on endothelial cells may facilitate leukocyte binding and transendothelial migration of cells and inflammatory factors. The aim of the present study was to assess levels of soluble cellular adhesion molecules, including intercellular adhesion molecule (ICAM)-1, vascular adhesion molecule (VCAM)-1, mucosal addressin cell adhesion molecule (MADCAM), junctional adhesion molecule (JAM-A) and neural cadherin (N-CAD) in patients with schizophrenia compared to healthy controls.
METHODS: The study population consists of 138 patients with schizophrenia-spectrum disorder, of whom 54 were drug-naïve, compared to 317 general population controls. The potential confounders age, gender, smoking and body mass index (BMI) were adjusted for in linear regression models.
RESULTS: The total patient group showed significantly higher levels of ICAM-1 (p < 0.001) and VCAM-1 (p < 0.001) compared to controls. Previously medicated patients showed higher ICAM-1 levels compared to drug-naïve patients (p = 0.042) and controls (p < 0.001), and elevated VCAM-1 levels compared to controls (p < 0.001). Drug-naive patients had elevated levels of VCAM-1 (p = 0.031) compared to controls.
CONCLUSIONS: In our study, patients with schizophrenia - including the drug-naïve - have higher levels of soluble CAMs compared to healthy controls. These findings suggest activation of the endothelial system as in inflammation.
METHODS: The study population consists of 138 patients with schizophrenia-spectrum disorder, of whom 54 were drug-naïve, compared to 317 general population controls. The potential confounders age, gender, smoking and body mass index (BMI) were adjusted for in linear regression models.
RESULTS: The total patient group showed significantly higher levels of ICAM-1 (p < 0.001) and VCAM-1 (p < 0.001) compared to controls. Previously medicated patients showed higher ICAM-1 levels compared to drug-naïve patients (p = 0.042) and controls (p < 0.001), and elevated VCAM-1 levels compared to controls (p < 0.001). Drug-naive patients had elevated levels of VCAM-1 (p = 0.031) compared to controls.
CONCLUSIONS: In our study, patients with schizophrenia - including the drug-naïve - have higher levels of soluble CAMs compared to healthy controls. These findings suggest activation of the endothelial system as in inflammation.
摘要：
背景：内皮炎症可能参与精神分裂症的发病机制，内皮细胞上的细胞粘附分子（CAM）可能促进白细胞结合和细胞和炎症因子的跨内皮迁移。本研究的目的是评估可溶性细胞粘附分子的水平，包括细胞间粘附分子(ICAM)-1、血管粘附分子(VCAM)-1、粘膜细胞粘附分子(MADCAM),与健康对照相比，精神分裂症患者的交界粘附分子（JAM-A）和神经钙粘蛋白（N-CAD）。
方法：研究人群包括138名精神分裂症谱系障碍患者，其中54人是吸毒，与317个一般人群对照相比。潜在的混杂因素年龄，性别,在线性回归模型中校正了吸烟和体重指数(BMI).
结果：与对照组相比，患者组的ICAM-1（p<0.001）和VCAM-1（p<0.001）水平明显更高。与未服药的患者（p=0.042）和对照组（p<0.001）相比，以前服药的患者表现出更高的ICAM-1水平，与对照组相比，VCAM-1水平升高（p<0.001）。与对照组相比，未接受药物治疗的患者的VCAM-1水平升高（p=0.031）。
结论：在我们的研究中，与健康对照组相比，精神分裂症患者-包括初治药物-具有更高水平的可溶性CAM。这些发现表明在炎症中激活内皮系统。
方法：研究人群包括138名精神分裂症谱系障碍患者，其中54人是吸毒，与317个一般人群对照相比。潜在的混杂因素年龄，性别,在线性回归模型中校正了吸烟和体重指数(BMI).
结果：与对照组相比，患者组的ICAM-1（p<0.001）和VCAM-1（p<0.001）水平明显更高。与未服药的患者（p=0.042）和对照组（p<0.001）相比，以前服药的患者表现出更高的ICAM-1水平，与对照组相比，VCAM-1水平升高（p<0.001）。与对照组相比，未接受药物治疗的患者的VCAM-1水平升高（p=0.031）。
结论：在我们的研究中，与健康对照组相比，精神分裂症患者-包括初治药物-具有更高水平的可溶性CAM。这些发现表明在炎症中激活内皮系统。
