Abstract：
UNASSIGNED: Spiny keratoderma is a rare entity presenting with minute keratotic spines on the palms and soles. Spiny keratoderma can be inherited or acquired, and the acquired form may be associated with underlying malignancy or systemic disease. Clinically, the differential diagnosis includes other digitate keratoses on acral sites, most notably arsenical keratosis, filiform verruca, and punctate porokeratosis. Biopsy findings typically include a column of parakeratosis overlying a diminished granular cell layer. In this article, we present 3 cases of acquired spiny keratoderma in patients with various systemic diseases, but no underlying malignancy.
摘要：
■棘皮病是一种罕见的实体，在手掌和脚底上有微小的角化棘。棘角化病可以遗传或后天获得,获得性形式可能与潜在的恶性肿瘤或全身性疾病相关。临床上,鉴别诊断包括肢端部位的其他指状性角化病，最著名的是砷性角化病,丝状疣,和点状的孔角化病。活检结果通常包括覆盖减少的颗粒细胞层的角化不全的柱。在这篇文章中,我们介绍了3例患有各种全身性疾病的获得性多刺性角化病，但没有潜在的恶性肿瘤.
