PDF(Pubmed)
Abstract：
UNASSIGNED: Our primary aim was to compare adult full-field ERG (ffERG) responses in albinism, idiopathic infantile nystagmus (IIN), and controls. A secondary aim was to investigate the effect of within-subject changes in nystagmus eye movements on ffERG responses.
UNASSIGNED: Dilated Ganzfeld flash ffERG responses were recorded using DTL electrodes under conditions of dark (standard and dim flash) and light adaptation in 68 participants with albinism, 43 with IIN, and 24 controls. For the primary aim, the effect of group and age on ffERG responses was investigated. For the secondary aim, null region characteristics were determined using eye movements recorded prior to ffERG recordings. ffERG responses were recorded near and away from the null regions of 18 participants also measuring the success rate of recordings.
UNASSIGNED: For the primary aim, age-adjusted photopic a- and b-wave amplitudes were consistently smaller in IIN compared with controls (P < 0.0001), with responses in both groups decreasing with age. In contrast, photopic a-wave amplitudes increased with age in albinism (P = 0.0035). For the secondary aim, more intense nystagmus significantly reduced the success rate of measurable responses. Within-subject changes in nystagmus intensity generated small, borderline significant differences in photopic b-wave peak times and a-and b-wave amplitudes under scotopic conditions with standard flash.
UNASSIGNED: Age-adjusted photopic ffERG responses are significantly reduced in IIN adding to the growing body of evidence of retinal abnormalities in IIN. Differences between photopic responses in albinism and controls depend on age. Success at obtaining ffERG responses could be improved by recording responses at the null region.
UNASSIGNED: Dilated Ganzfeld flash ffERG responses were recorded using DTL electrodes under conditions of dark (standard and dim flash) and light adaptation in 68 participants with albinism, 43 with IIN, and 24 controls. For the primary aim, the effect of group and age on ffERG responses was investigated. For the secondary aim, null region characteristics were determined using eye movements recorded prior to ffERG recordings. ffERG responses were recorded near and away from the null regions of 18 participants also measuring the success rate of recordings.
UNASSIGNED: For the primary aim, age-adjusted photopic a- and b-wave amplitudes were consistently smaller in IIN compared with controls (P < 0.0001), with responses in both groups decreasing with age. In contrast, photopic a-wave amplitudes increased with age in albinism (P = 0.0035). For the secondary aim, more intense nystagmus significantly reduced the success rate of measurable responses. Within-subject changes in nystagmus intensity generated small, borderline significant differences in photopic b-wave peak times and a-and b-wave amplitudes under scotopic conditions with standard flash.
UNASSIGNED: Age-adjusted photopic ffERG responses are significantly reduced in IIN adding to the growing body of evidence of retinal abnormalities in IIN. Differences between photopic responses in albinism and controls depend on age. Success at obtaining ffERG responses could be improved by recording responses at the null region.
摘要：
■我们的主要目的是比较白化病的成人全视野ERG（ffERG）反应，特发性婴儿眼球震颤（IIN），和控制。次要目的是研究眼球震颤的受试者内部变化对ffERG反应的影响。
■使用DTL电极在黑暗（标准和昏暗闪光）和光线适应条件下，在68名白化病参与者中记录了稀释的Ganzfeld闪光ffERG反应，43与IIN，24个控制对于主要目标，研究了群体和年龄对ffERG反应的影响.为了次要目标，使用在ffERG记录之前记录的眼球运动来确定零区域特征。在18名参与者的空区域附近和远处记录了ffERG反应，并测量了记录的成功率。
■对于主要目标，与对照组相比，IIN的年龄调整后的明视a波和b波振幅始终较小（P<0.0001），两组的反应都随着年龄的增长而下降。相比之下,白化病的明视a波振幅随年龄增长而增加（P=0.0035）。为了次要目标，更强烈的眼球震颤显着降低了可测量反应的成功率。受试者内产生的眼球震颤强度变化小，在标准闪光的暗视条件下，明视b波峰值时间以及a和b波振幅的边界显着差异。
■在IIN中，年龄调整的明视ffERG反应显着降低，增加了IIN中视网膜异常的证据。白化病和对照组的明视反应之间的差异取决于年龄。获得ffERG应答的成功可以通过在空区域记录应答来提高。
■使用DTL电极在黑暗（标准和昏暗闪光）和光线适应条件下，在68名白化病参与者中记录了稀释的Ganzfeld闪光ffERG反应，43与IIN，24个控制对于主要目标，研究了群体和年龄对ffERG反应的影响.为了次要目标，使用在ffERG记录之前记录的眼球运动来确定零区域特征。在18名参与者的空区域附近和远处记录了ffERG反应，并测量了记录的成功率。
■对于主要目标，与对照组相比，IIN的年龄调整后的明视a波和b波振幅始终较小（P<0.0001），两组的反应都随着年龄的增长而下降。相比之下,白化病的明视a波振幅随年龄增长而增加（P=0.0035）。为了次要目标，更强烈的眼球震颤显着降低了可测量反应的成功率。受试者内产生的眼球震颤强度变化小，在标准闪光的暗视条件下，明视b波峰值时间以及a和b波振幅的边界显着差异。
■在IIN中，年龄调整的明视ffERG反应显着降低，增加了IIN中视网膜异常的证据。白化病和对照组的明视反应之间的差异取决于年龄。获得ffERG应答的成功可以通过在空区域记录应答来提高。
