Abstract：
As one of the most urgent social and health problems in the world, neurodegenerative diseases have always been of interest to researchers. However, the pathological mechanisms and therapeutic approaches are not achieved. In addition to the established roles of oxidative stress, inflammation and immune response, changes of gut microbiota are also closely related to the pathogenesis of neurodegenerative diseases. Gut microbiota is the central player of the gut-brain axis, the dynamic bidirectional communication pathway between gut microbiota and central nervous system, and emerging insights have confirmed its indispensability in the development of neurodegenerative diseases. In this review, we discuss the complex relationship between gut microbiota and the central nervous system from the perspective of the gut-brain axis; review the mechanism of microbiota for the modulation different neurodegenerative diseases and discuss how different dietary patterns affect neurodegenerative diseases via gut microbiota; and prospect the employment of gut microbiota in the therapeutic approach to those diseases. © 2024 Society of Chemical Industry.
摘要：
作为世界上最紧迫的社会和健康问题之一，神经退行性疾病一直被研究者所吸引。然而,病理机制和治疗方法没有实现。除了确定的氧化应激的作用，炎症和免疫反应，肠道菌群的变化也与神经退行性疾病的发病机制密切相关。肠道微生物群是肠道-脑轴的中心角色，肠道菌群与中枢神经系统之间的动态双向通讯通路，和新兴的见解已经证实了它在神经退行性疾病的发展中不可或缺。在这次审查中,我们从肠-脑轴的角度讨论了肠道菌群与中枢神经系统之间的复杂关系，综述了微生物群对不同神经退行性疾病的调控机制，并总结了不同饮食模式如何通过肠道微生物群影响神经退行性疾病，并展望了肠道菌群在这些疾病治疗中的应用。本文受版权保护。保留所有权利。
