PDF(Pubmed)
Abstract：
UNASSIGNED: Bowen\'s disease is a squamous cell carcinoma in situ, the most common malignancy of the nail unit. Presenting more frequently in the fingernails, common risk factors include ionizing radiation, oral exposure to arsenic or pesticides, dyskeratosis congenita, and quite commonly diverse subtypes of HPV. We report the first case of multiple periungual pigmented Bowen\'s disease in a pediatric patient.
UNASSIGNED: A healthy 13-year-old boy presented with a 9-month history of a pigmented erythematous patch on the proximal nail fold of his 3rd right finger without associated symptoms. A punch biopsy was taken, and the diagnosis of Bowen\'s disease was made. The patient received photodynamic therapy and three cycles of imiquimod without response, and two new lesions appeared on the first and second right fingers. Surgical removal was performed on all lesions. A polymerase chain reaction detected an HPV type 16.
UNASSIGNED: Multiple periungual Bowen\'s disease is rare, with the most frequent risk factors being HPV infection and chronic immunosuppression. Less than 10% of the cases present as longitudinal melanonychia. To date, there are no previous reports of multiple pigmented periungual Bowen\'s disease. HPV-induced Bowen\'s disease is usually present in adults aged between 22 and 89 years as persistent verrucae. In this case, koilocytosis and the fact that all lesions appeared on the right hand are suggestive of HPV infection.
UNASSIGNED: A healthy 13-year-old boy presented with a 9-month history of a pigmented erythematous patch on the proximal nail fold of his 3rd right finger without associated symptoms. A punch biopsy was taken, and the diagnosis of Bowen\'s disease was made. The patient received photodynamic therapy and three cycles of imiquimod without response, and two new lesions appeared on the first and second right fingers. Surgical removal was performed on all lesions. A polymerase chain reaction detected an HPV type 16.
UNASSIGNED: Multiple periungual Bowen\'s disease is rare, with the most frequent risk factors being HPV infection and chronic immunosuppression. Less than 10% of the cases present as longitudinal melanonychia. To date, there are no previous reports of multiple pigmented periungual Bowen\'s disease. HPV-induced Bowen\'s disease is usually present in adults aged between 22 and 89 years as persistent verrucae. In this case, koilocytosis and the fact that all lesions appeared on the right hand are suggestive of HPV infection.
摘要：
■Bowen病是一种原位鳞状细胞癌，指甲最常见的恶性肿瘤。更频繁地出现在指甲里，常见的危险因素包括电离辐射，口服砷或杀虫剂，先天性角化障碍,和相当常见的不同亚型的HPV。我们报告了第一例儿科患者的多发性甲周色素沉着Bowen病。
■一个健康的13岁男孩，有9个月的历史，他的第3个右手指的近端指甲褶皱上有一个色素性红斑，没有相关症状。做了穿刺活检，并做出了Bowen病的诊断。患者接受光动力疗法和三个周期的咪喹莫特无反应，两个新的病变出现在第一和第二右手指上。对所有病变进行手术切除。聚合酶链反应检测到HPV16型。
■多发性甲周Bowen病很少见，最常见的危险因素是HPV感染和慢性免疫抑制。少于10％的病例表现为纵向黑甲。迄今为止,以前没有多发性色素性甲周Bowen病的报道。HPV诱导的Bowen病通常在22至89岁的成年人中表现为持续性疣。在这种情况下,koilocytosis和所有病变出现在右手的事实提示HPV感染。
■一个健康的13岁男孩，有9个月的历史，他的第3个右手指的近端指甲褶皱上有一个色素性红斑，没有相关症状。做了穿刺活检，并做出了Bowen病的诊断。患者接受光动力疗法和三个周期的咪喹莫特无反应，两个新的病变出现在第一和第二右手指上。对所有病变进行手术切除。聚合酶链反应检测到HPV16型。
■多发性甲周Bowen病很少见，最常见的危险因素是HPV感染和慢性免疫抑制。少于10％的病例表现为纵向黑甲。迄今为止,以前没有多发性色素性甲周Bowen病的报道。HPV诱导的Bowen病通常在22至89岁的成年人中表现为持续性疣。在这种情况下,koilocytosis和所有病变出现在右手的事实提示HPV感染。
