PDF(Pubmed)
Abstract：
Cancer is still one of the leading causes of death, with an estimated 19.3 million new cases every year. Our paper presents the tumor-suppressing effect of Taenia crassiceps and Mesocestoides corti on B16F10 melanoma, the intraperitoneal application of which followed the experimental infection with these tapeworms, resulting in varying degrees of effectiveness in two strains of mice. In the case of M. corti-infected ICR mice, a strong tumor growth suppression occurred, which was accompanied by a significant reduction in the formation of distant metastases in the liver and lung. Tapeworm-infected C57BL/6J mice also showed a suppression of tumor growth and, in addition, the overall survival of infected C57BL/6J mice was significantly improved. Experiments with potential cross-reaction of melanoma and tapeworm antigens with respective specific antibodies, restimulation of spleen T cells, or the direct effect of tapeworm excretory-secretory products on melanoma cells in vitro could not explain the phenomenon. However, infections with T. crassiceps and M. corti increased the number of leukocytes possibly involved in anti-tumor immunity in the peritoneal cavity of both ICR and C57BL/6J mice. This study unveils the complex interplay between tapeworm infections, immune responses, and melanoma progression, emphasizing the need for further exploration of the mechanisms driving observed tumor-suppressive effects.
摘要：
癌症仍然是导致死亡的主要原因之一，估计每年有1930万新病例。我们的论文介绍了头肌带虫和中胚层对B16F10黑色素瘤的肿瘤抑制作用，腹膜内的应用是在这些tape虫的实验性感染之后，导致两种小鼠不同程度的有效性。在M.corti感染的ICR小鼠的情况下，发生了强烈的肿瘤生长抑制，伴随着肝脏和肺部远处转移的形成显着减少。线虫感染的C57BL/6J小鼠也显示出肿瘤生长的抑制作用，此外,感染C57BL/6J小鼠的总生存期显著提高。黑色素瘤和tape虫抗原与各自特异性抗体的潜在交叉反应的实验，脾T细胞的再刺激，或者tape虫排泄分泌产物对黑色素瘤细胞的直接作用不能解释这种现象。然而,T.crassiceps和M.corti感染增加了ICR和C57BL/6J小鼠腹膜腔中可能参与抗肿瘤免疫的白细胞数量。这项研究揭示了tape虫感染之间复杂的相互作用，免疫反应，和黑色素瘤进展，强调需要进一步探索驱动观察到的肿瘤抑制作用的机制。
