PDF(Pubmed)
Abstract：
Cryptococcosis is a fungal infectious disease that enormously impacts human health worldwide. Cryptococcal meningitis is the most severe disease caused by the fungus Cryptococcus, and can lead to death, if left untreated. Many patients develop resistance and progress to death even after treatment. It requires a prolonged treatment course in people with AIDS. This narrative review provides an evidence-based summary of the current treatment modalities and future trial options, including newer ones, namely, 18B7, T-2307, VT-1598, AR12, manogepix, and miltefosine. This review also evaluated the management and empiric treatment of cryptococcus meningitis. The disease can easily evade diagnosis with subacute presentation. Despite the severity of the disease, treatment options for cryptococcosis remain limited, and more research is needed.
摘要：
隐球菌病是一种真菌传染病，在全球范围内对人类健康产生巨大影响。隐球菌性脑膜炎是由真菌隐球菌引起的最严重的疾病，会导致死亡,如果不及时治疗。许多患者即使在治疗后也会产生耐药性并进展至死亡。它需要延长艾滋病患者的疗程。这篇叙述性综述提供了当前治疗方式和未来试验选择的循证总结。包括较新的，即,18B7,T-2307,VT-1598,AR12,manogepix,还有米替福辛.本文还评估了隐球菌性脑膜炎的管理和经验治疗。该疾病很容易以亚急性表现逃避诊断。尽管疾病严重,隐球菌病的治疗选择仍然有限，需要更多的研究。
