PDF(Pubmed)
Abstract：
UNASSIGNED: Retinopathy of prematurity is a significant global cause of childhood blindness. This study aims to identify serum biomarkers that are associated with the development of ROP.
UNASSIGNED: A systematic review and meta-analysis was conducted using PRISMA guidelines. Three databases were searched (Pubmed, Scopus and Web of Science) from 2003 to March 2023. Only studies investigating serum biomarker levels in preterm infants (<37 weeks gestation) were included.
UNASSIGNED: Meta-analysis suggests that low serum IGF-1 levels have a strong association with the development of ROP [SMD (95% CI) of -.46 [-.63, -.30], p < .001]. Meta-analysis suggests that higher serum glucose levels were associated with the development of ROP [SMD (95% CI) of 1.25 [.94, 1.55], p < .001]. Meta-analysis suggests that thrombocytopenia is associated with the development of ROP [SMD (95% CI) of -.62 [-.86, -.37], p < .001].
UNASSIGNED: Low levels of serum IGF-1, high levels of serum glucose and thrombocytopenia all appear to have the strongest association with the development of ROP out of the 63 biomarkers investigated in this review. These associations highlight their potential use as diagnostic biomarkers in ROP, though further research is needed to establish the exact relationship between these biomarkers and disease pathogenesis.
UNASSIGNED: A systematic review and meta-analysis was conducted using PRISMA guidelines. Three databases were searched (Pubmed, Scopus and Web of Science) from 2003 to March 2023. Only studies investigating serum biomarker levels in preterm infants (<37 weeks gestation) were included.
UNASSIGNED: Meta-analysis suggests that low serum IGF-1 levels have a strong association with the development of ROP [SMD (95% CI) of -.46 [-.63, -.30], p < .001]. Meta-analysis suggests that higher serum glucose levels were associated with the development of ROP [SMD (95% CI) of 1.25 [.94, 1.55], p < .001]. Meta-analysis suggests that thrombocytopenia is associated with the development of ROP [SMD (95% CI) of -.62 [-.86, -.37], p < .001].
UNASSIGNED: Low levels of serum IGF-1, high levels of serum glucose and thrombocytopenia all appear to have the strongest association with the development of ROP out of the 63 biomarkers investigated in this review. These associations highlight their potential use as diagnostic biomarkers in ROP, though further research is needed to establish the exact relationship between these biomarkers and disease pathogenesis.
摘要：
■早产儿视网膜病是全球儿童失明的重要原因。这项研究旨在鉴定与ROP发展相关的血清生物标志物。
■使用PRISMA指南进行系统评价和荟萃分析。搜索了三个数据库(Pubmed，Scopus和WebofScience）从2003年到2023年3月。仅包括调查早产儿（<37孕周）血清生物标志物水平的研究。
■荟萃分析表明，低血清IGF-1水平与ROP[SMD（95％CI）-0.46[-.63，-.30]的发展有很强的关联，p<.001]。荟萃分析表明，较高的血清葡萄糖水平与ROP的发展有关[SMD（95％CI）为1.25[.94，1.55]，p<.001]。Meta分析提示血小板减少与ROP[SMD(95%CI)-0.62[-.86,-.37]的发展有关,p<.001]。
■低水平的血清IGF-1，高水平的血清葡萄糖和血小板减少症似乎都与本综述中研究的63种生物标志物中的ROP的发展具有最强的关联。这些关联凸显了它们在ROP中作为诊断生物标志物的潜在用途，尽管需要进一步的研究来确定这些生物标志物与疾病发病机理之间的确切关系。
■使用PRISMA指南进行系统评价和荟萃分析。搜索了三个数据库(Pubmed，Scopus和WebofScience）从2003年到2023年3月。仅包括调查早产儿（<37孕周）血清生物标志物水平的研究。
■荟萃分析表明，低血清IGF-1水平与ROP[SMD（95％CI）-0.46[-.63，-.30]的发展有很强的关联，p<.001]。荟萃分析表明，较高的血清葡萄糖水平与ROP的发展有关[SMD（95％CI）为1.25[.94，1.55]，p<.001]。Meta分析提示血小板减少与ROP[SMD(95%CI)-0.62[-.86,-.37]的发展有关,p<.001]。
■低水平的血清IGF-1，高水平的血清葡萄糖和血小板减少症似乎都与本综述中研究的63种生物标志物中的ROP的发展具有最强的关联。这些关联凸显了它们在ROP中作为诊断生物标志物的潜在用途，尽管需要进一步的研究来确定这些生物标志物与疾病发病机理之间的确切关系。
