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Abstract：
Graves\' ophthalmopathy (GO) is an extrathyroidal manifestation of Graves\' disease, Orbital fibroblasts (OFs) are recognized as key players in GO pathogenesis, involved in orbital inflammation, tissue remodeling, and fibrosis. This study offers a primary exploration of cell behavior and characteristics on OFs from GO (GO-OFs), and compared to OFs from healthy control (HC-OFs). Results reveal that GO-OFs exhibit delayed migration from tissue fragments, while no significant difference in cell proliferation is observed between GO-OFs and HC-OFs. Aberrant expression pattern of surface proteins Thy-1, TSHR, and IGF-1R suggests shared autoantigens and pathways between GO and GD, contributing to inflammation and fibrosis. Investigations into cytokine responses unveil elevated secretion of hyaluronic acid (HA) and prostaglandin E2 (PGE2) in GO-OFs, emphasizing their role in tissue remodeling. These findings deepen our understanding of OFs in GO pathogenesis, offering potential therapeutic avenues.
摘要：
Graves眼病（GO）是Graves病的甲状腺外表现，眼眶成纤维细胞（OFs）被认为是GO发病机制的关键参与者，与眼眶炎症有关，组织重塑,和纤维化。这项研究提供了对GO（GO-OFs）的细胞行为和特征的初步探索，并与来自健康对照的OF(HC-OF)进行比较。结果表明，GO-OFs表现出从组织碎片的延迟迁移，而在GO-OF和HC-OF之间没有观察到细胞增殖的显著差异。Thy-1,TSHR,IGF-1R提示GO和GD之间共有自身抗原和途径，导致炎症和纤维化。细胞因子反应的研究揭示了GO-OFs中透明质酸（HA）和前列腺素E2（PGE2）的分泌升高，强调它们在组织重塑中的作用。这些发现加深了我们对OFs在GO发病机制中的理解，提供潜在的治疗途径。
