Abstract：
Lifestyle interventions remain the treatment of choice for patients with obesity and metabolic complications, yet are difficult to maintain and often lead to cycles of weight loss and regain (weight cycling). Literature on weight cycling remains controversial and we therefore investigated the association between weight cycling and metabolic complications using preexistent obese mice. Ldlr-/-.Leiden mice received a high-fat diet (HFD) for 20 weeks to induce obesity. Subsequently, weight-cycled mice were switched between the healthy chow diet and HFD for four 2-week periods and compared to mice that received HFD for the total study period. Repeated weight cycling tended to decrease body weight and significantly reduced fat mass, whereas adipose tissue inflammation was similar relative to HFD controls. Weight cycling did not significantly affect blood glucose or plasma insulin levels yet significantly reduced plasma free fatty acid and alanine transaminase/aspartate transaminase levels. Hepatic macrovesicular steatosis was similar and microvesicular steatosis tended to be increased upon weight cycling. Weight cycling resulted in a robust decrease in hepatic inflammation compared to HFD controls while hepatic fibrosis and atherosclerosis development were not affected. These results argue against the postulate that repeated weight cycling leads to unfavorable metabolic effects, when compared to a continuous unhealthy lifestyle, and in fact revealed beneficial effects on hepatic inflammation, an important hallmark of non-alcoholic steatohepatitis.
摘要：
生活方式干预仍然是肥胖和代谢并发症患者的首选治疗方法。但是难以维持，并且经常导致体重减轻和恢复（体重循环）的循环。关于体重循环的文献仍然存在争议，因此我们使用先前存在的肥胖小鼠研究了体重循环与代谢并发症之间的关联。LDLR-/-。莱顿小鼠接受高脂肪饮食(HFD)20周以诱导肥胖。随后，将体重循环的小鼠在健康饮食和HFD之间切换4个2周,并与在整个研究期间接受HFD的小鼠进行比较.重复的体重循环倾向于降低体重并显着减少脂肪量，而脂肪组织炎症与HFD对照相似。体重循环并未显着影响血糖或血浆胰岛素水平，但显着降低了血浆游离脂肪酸和丙氨酸转氨酶/天冬氨酸转氨酶水平。肝大泡性脂肪变性相似，而体重循环后，小泡性脂肪变性倾向于增加。与HFD对照相比，体重循环导致肝脏炎症大幅减少，而肝纤维化和动脉粥样硬化发展不受影响。这些结果与重复的体重循环导致不利的代谢作用的假设相反，与持续不健康的生活方式相比，事实上揭示了对肝脏炎症的有益作用，非酒精性脂肪性肝炎的重要标志。
