PDF(Pubmed)
Abstract：
BACKGROUND: Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was firstly described in 2016. Since NIFTP is thought a non-malignant tumor, the Bethesda system for thyroid cytology proposes two estimations of risk of malignancy of the diagnostic categories, one considering NIFTP as cancer and another one considering it as a benign neoplasm. The present study aimed to review NIFTPs in a single center, re-assess them across categories of three Thyroid Imaging Reporting and Data Systems (TIRADSs), and define the indication for biopsy according to the category-specific size cut-offs.
METHODS: The study period was from 2017 to 2023. The institutional database was searched for histologically proven NIFTPs with preoperative ultrasound images. NIFTPs were re-assessed according to the American College of Radiology (ACR), European (EU), and Korean (K) TIRADSs. The indication for biopsy was defined according to TIRADS category-specific size threshold.
RESULTS: Twenty NIFTPs from 19 patients were included. The median size of the NIFTPs was 23 mm. According to ultrasound, 80-85% of NIFTPs were at low-intermediate risk and 5-15% at high risk without significant difference among the tree TIRADSs (p = 0.91). The indication for FNA, according to three TIRADSs, was found in 52-58% of cases with no significant difference among systems (p = 0.96).
CONCLUSIONS: NIFTPs have heterogeneous presentation according to TIRADSs with very low indication rate for FNA.
METHODS: The study period was from 2017 to 2023. The institutional database was searched for histologically proven NIFTPs with preoperative ultrasound images. NIFTPs were re-assessed according to the American College of Radiology (ACR), European (EU), and Korean (K) TIRADSs. The indication for biopsy was defined according to TIRADS category-specific size threshold.
RESULTS: Twenty NIFTPs from 19 patients were included. The median size of the NIFTPs was 23 mm. According to ultrasound, 80-85% of NIFTPs were at low-intermediate risk and 5-15% at high risk without significant difference among the tree TIRADSs (p = 0.91). The indication for FNA, according to three TIRADSs, was found in 52-58% of cases with no significant difference among systems (p = 0.96).
CONCLUSIONS: NIFTPs have heterogeneous presentation according to TIRADSs with very low indication rate for FNA.
摘要：
背景：2016年首次描述了具有乳头状样细胞核特征（NIFTP）的非侵袭性滤泡性甲状腺肿瘤。由于NIFTP被认为是非恶性肿瘤，Bethesda甲状腺细胞学系统提出了两种诊断类别的恶性肿瘤风险估计，一个人认为NIFTP是癌症，另一个人认为它是良性肿瘤。本研究旨在回顾单中心的NIFTP，在三个甲状腺成像报告和数据系统（TIRADS）的类别中重新评估它们，并根据特定类别的切点大小定义活检的指征。
方法：研究期为2017年至2023年。在机构数据库中搜索经组织学证实的具有术前超声图像的NIFTP。根据美国放射学会(ACR)重新评估NIFTP，欧洲(欧盟),和韩国（K）TIRADS。根据TIRADS类别特异性大小阈值定义活检指征。
结果：纳入19例患者的20个NIFTP。NIFTP的中值尺寸为23mm。根据超声波,80-85％的NIFTP处于低-中等风险，5-15％处于高风险，在树TIRADS之间没有显着差异（p=0.91）。FNA指示,根据三个TIRADS，在52-58％的病例中发现，系统之间没有显着差异（p=0.96）。
结论：根据TIRADS，NIFTP具有异质性表现，FNA适应症率非常低。
方法：研究期为2017年至2023年。在机构数据库中搜索经组织学证实的具有术前超声图像的NIFTP。根据美国放射学会(ACR)重新评估NIFTP，欧洲(欧盟),和韩国（K）TIRADS。根据TIRADS类别特异性大小阈值定义活检指征。
结果：纳入19例患者的20个NIFTP。NIFTP的中值尺寸为23mm。根据超声波,80-85％的NIFTP处于低-中等风险，5-15％处于高风险，在树TIRADS之间没有显着差异（p=0.91）。FNA指示,根据三个TIRADS，在52-58％的病例中发现，系统之间没有显着差异（p=0.96）。
结论：根据TIRADS，NIFTP具有异质性表现，FNA适应症率非常低。
