Abstract：
BACKGROUND: Surgical management of large ventral hernias (VH) has remained a challenge. Various techniques like anterior component separation and posterior component separation (PCS) with transversus abdominis release (TAR) have been employed. Despite the initial success, the long-term efficacy of TAR is not yet comprehensively studied. Authors aimed to investigate the early-, medium-, and long-term outcomes and health-related quality of life (QoL) in patients treated with PCS and TAR.
METHODS: This multicenter retrospective study analyzed data of 308 patients who underwent open PCS with TAR for primary or recurrent complex abdominal hernias between 2015 and 2020. The primary endpoint was the rate of hernia recurrence (HR) and mesh bulging (MB) at 3, 6, 12, 24, and 36 months. Secondary outcomes included surgical site events and QoL, assessed using EuraHS-QoL score.
RESULTS: The average follow-up was 38.3 ± 12.7 months. The overall HR rate was 3.5% and the MB rate was 4.7%. Most of the recurrences were detected by clinical and ultrasound examination. QoL metrics showed improvement post-surgery.
CONCLUSIONS: This study supports the long-term efficacy of PCS with TAR in the treatment of large and complex VH, with a low recurrence rate and an improvement in QoL. Further research is needed for a more in-depth understanding of these outcomes and the factors affecting them.
METHODS: This multicenter retrospective study analyzed data of 308 patients who underwent open PCS with TAR for primary or recurrent complex abdominal hernias between 2015 and 2020. The primary endpoint was the rate of hernia recurrence (HR) and mesh bulging (MB) at 3, 6, 12, 24, and 36 months. Secondary outcomes included surgical site events and QoL, assessed using EuraHS-QoL score.
RESULTS: The average follow-up was 38.3 ± 12.7 months. The overall HR rate was 3.5% and the MB rate was 4.7%. Most of the recurrences were detected by clinical and ultrasound examination. QoL metrics showed improvement post-surgery.
CONCLUSIONS: This study supports the long-term efficacy of PCS with TAR in the treatment of large and complex VH, with a low recurrence rate and an improvement in QoL. Further research is needed for a more in-depth understanding of these outcomes and the factors affecting them.
摘要：
背景：大型腹侧疝（VH）的手术治疗仍然是一个挑战。已经采用了各种技术，例如具有腹横肌释放（TAR）的前成分分离和后成分分离（PCS）。尽管最初取得了成功,TAR的长期疗效尚未全面研究。作者旨在调查早期的，medium-,以及接受PCS和TAR治疗的患者的长期结局和健康相关生活质量（QoL）。
方法：这项多中心回顾性研究分析了在2015年至2020年期间因原发性或复发性复杂性腹部疝接受TAR开放式PCS治疗的308例患者的数据。主要终点是3、6、12、24和36个月时的疝复发率（HR）和网片膨出率（MB）。次要结局包括手术部位事件和QoL,使用EuraHS-QoL评分进行评估。
结果：平均随访38.3±12.7个月。总体HR率为3.5%,MB率为4.7%。大多数复发是通过临床和超声检查发现的。QoL指标显示术后改善。
结论：本研究支持PCS联合TAR治疗大且复杂VH的长期疗效，复发率低，QoL改善。需要进一步的研究才能更深入地了解这些结果及其影响因素。
方法：这项多中心回顾性研究分析了在2015年至2020年期间因原发性或复发性复杂性腹部疝接受TAR开放式PCS治疗的308例患者的数据。主要终点是3、6、12、24和36个月时的疝复发率（HR）和网片膨出率（MB）。次要结局包括手术部位事件和QoL,使用EuraHS-QoL评分进行评估。
结果：平均随访38.3±12.7个月。总体HR率为3.5%,MB率为4.7%。大多数复发是通过临床和超声检查发现的。QoL指标显示术后改善。
结论：本研究支持PCS联合TAR治疗大且复杂VH的长期疗效，复发率低，QoL改善。需要进一步的研究才能更深入地了解这些结果及其影响因素。
