Abstract：
BACKGROUND: Perforation of peptic ulcer (PPU) is the most morbid complication of peptic ulcer disease (PUD) with scant recent reports from sub-Saharan Africa. The aim of this study was to describe a PPU series from a single centre in South Africa and contrast the findings with other recent reports from sub-Saharan Africa.
METHODS: A retrospective study of PPU at Kalafong Hospital in Pretoria was performed. The relationship of patient demographics, risk factors, ulcer pathology and severity scores to mortality were analysed. Recent similar reports from sub-Saharan Africa were reviewed and the findings compared to the current study and findings from high income countries (HIC).
RESULTS: The study comprised 121 patients. The majority were black men with an average age of 46.6 years, with few comorbidities. A large proportion of patients admitted to risk factors and most presented to hospital 48 hours after the onset of symptoms. The majority (71%) of the perforations occurred in the stomach. The patient sex, age, risk factors and the mortality at 4% were similar to other African studies, although perforations were mainly duodenal in most of the African studies. The median age of patients in the East African studies was lower by 13 years. Patients in HIC series of PPU were older, more likely to be female, have duodenal perforations and a higher mortality than in the African series.
CONCLUSIONS: Patients were mostly smokers, presented late to hospital and had gastric perforations. The findings of low mortality and male predominance concurred with those of other sub-Saharan African reports and were the opposite of trends in HIC.
METHODS: A retrospective study of PPU at Kalafong Hospital in Pretoria was performed. The relationship of patient demographics, risk factors, ulcer pathology and severity scores to mortality were analysed. Recent similar reports from sub-Saharan Africa were reviewed and the findings compared to the current study and findings from high income countries (HIC).
RESULTS: The study comprised 121 patients. The majority were black men with an average age of 46.6 years, with few comorbidities. A large proportion of patients admitted to risk factors and most presented to hospital 48 hours after the onset of symptoms. The majority (71%) of the perforations occurred in the stomach. The patient sex, age, risk factors and the mortality at 4% were similar to other African studies, although perforations were mainly duodenal in most of the African studies. The median age of patients in the East African studies was lower by 13 years. Patients in HIC series of PPU were older, more likely to be female, have duodenal perforations and a higher mortality than in the African series.
CONCLUSIONS: Patients were mostly smokers, presented late to hospital and had gastric perforations. The findings of low mortality and male predominance concurred with those of other sub-Saharan African reports and were the opposite of trends in HIC.
摘要：
背景：消化性溃疡穿孔（PPU）是消化性溃疡疾病（PUD）最病态的并发症，最近撒哈拉以南非洲的报道很少。这项研究的目的是描述来自南非单个中心的PPU系列，并将调查结果与撒哈拉以南非洲的其他最新报告进行对比。
方法：对比勒陀利亚Kalafong医院的PPU进行了回顾性研究。患者人口统计的关系，危险因素，分析了溃疡病理和严重程度评分对死亡率的影响.审查了撒哈拉以南非洲最近的类似报告，并将调查结果与当前研究和高收入国家（HIC）的调查结果进行了比较。
结果：该研究包括121名患者。大多数是黑人男性，平均年龄为46.6岁，几乎没有合并症。很大一部分患者接受了危险因素，大多数患者在症状发作48小时后住院。大部分（71％）的穿孔发生在胃中。病人的性别，年龄,危险因素和4%的死亡率与其他非洲研究相似，尽管在大多数非洲研究中穿孔主要是十二指肠穿孔。东非研究中患者的中位年龄降低了13岁。HIC系列PPU患者年龄较大，更有可能是女性，十二指肠穿孔，死亡率高于非洲系列。
结论：患者大多是吸烟者，住院晚，胃穿孔。死亡率低和男性占主导地位的调查结果与撒哈拉以南非洲其他报告的结论一致，与HIC的趋势相反。
方法：对比勒陀利亚Kalafong医院的PPU进行了回顾性研究。患者人口统计的关系，危险因素，分析了溃疡病理和严重程度评分对死亡率的影响.审查了撒哈拉以南非洲最近的类似报告，并将调查结果与当前研究和高收入国家（HIC）的调查结果进行了比较。
结果：该研究包括121名患者。大多数是黑人男性，平均年龄为46.6岁，几乎没有合并症。很大一部分患者接受了危险因素，大多数患者在症状发作48小时后住院。大部分（71％）的穿孔发生在胃中。病人的性别，年龄,危险因素和4%的死亡率与其他非洲研究相似，尽管在大多数非洲研究中穿孔主要是十二指肠穿孔。东非研究中患者的中位年龄降低了13岁。HIC系列PPU患者年龄较大，更有可能是女性，十二指肠穿孔，死亡率高于非洲系列。
结论：患者大多是吸烟者，住院晚，胃穿孔。死亡率低和男性占主导地位的调查结果与撒哈拉以南非洲其他报告的结论一致，与HIC的趋势相反。
