PDF(Pubmed)
Abstract：
UNASSIGNED: Tuberculosis destroyed lung constitutes a significant worldwide public health challenge, little is known about its associated risk factors and prognosis. Our study aimed to identify the risk factors of tuberculosis destroyed lung among pulmonary tuberculosis and structural lung diseases.
UNASSIGNED: Between January 2019 and December 2021, a case-control study was conducted at the Third People\'s Hospital of Shenzhen in China. We collected the clinical data among patients with pulmonary tuberculosis and structural lung diseases. Cases were defined as patients with tuberculosis destroyed lung. Controls were not diagnosed with the tuberculosis destroyed lung. A binary logistic regression was performed.
UNASSIGNED: In our study, a total of 341 patients met the inclusion criteria, including 182 cases and 159 controls. We found that age ranges of 46-60 years (aOR: 4.879; 95% CI: 2.338-10.180), >60 years (aOR: 3.384; 95% CI: 1.481-7.735); history of TB treatment (aOR: 2.729; 95% CI: 1.606-4.638); malnutrition (aOR: 5.126; 95% CI: 1.359-19.335); respiratory failure (aOR: 5.080; 95% CI: 1.491-17.306); and bronchiarctia (aOR: 3.499; 95% CI: 1.330-9.209) were the independent risk factors for tuberculosis destroyed lung. Conversely, having a normal (aOR: 0.207; 95% CI: 0.116-0.371) or overweight BMI (aOR: 0.259; 95% CI: 0.090-0.747) emerged as a protective factor against tuberculosis destroyed lung.
UNASSIGNED: This study indicated that tuberculosis destroyed lung is a common condition among patients with pulmonary tuberculosis and structural lung diseases. The independent risk factors for tuberculosis destroyed lung were identified as being within the age groups of 46-60 and over 60 years, having a previous history of TB treatment, malnutrition, respiratory failure, and bronchiarctia. It is essential to closely monitor patients possessing these risk factors to prevent the progression towards tuberculosis destroyed lung.
UNASSIGNED: Between January 2019 and December 2021, a case-control study was conducted at the Third People\'s Hospital of Shenzhen in China. We collected the clinical data among patients with pulmonary tuberculosis and structural lung diseases. Cases were defined as patients with tuberculosis destroyed lung. Controls were not diagnosed with the tuberculosis destroyed lung. A binary logistic regression was performed.
UNASSIGNED: In our study, a total of 341 patients met the inclusion criteria, including 182 cases and 159 controls. We found that age ranges of 46-60 years (aOR: 4.879; 95% CI: 2.338-10.180), >60 years (aOR: 3.384; 95% CI: 1.481-7.735); history of TB treatment (aOR: 2.729; 95% CI: 1.606-4.638); malnutrition (aOR: 5.126; 95% CI: 1.359-19.335); respiratory failure (aOR: 5.080; 95% CI: 1.491-17.306); and bronchiarctia (aOR: 3.499; 95% CI: 1.330-9.209) were the independent risk factors for tuberculosis destroyed lung. Conversely, having a normal (aOR: 0.207; 95% CI: 0.116-0.371) or overweight BMI (aOR: 0.259; 95% CI: 0.090-0.747) emerged as a protective factor against tuberculosis destroyed lung.
UNASSIGNED: This study indicated that tuberculosis destroyed lung is a common condition among patients with pulmonary tuberculosis and structural lung diseases. The independent risk factors for tuberculosis destroyed lung were identified as being within the age groups of 46-60 and over 60 years, having a previous history of TB treatment, malnutrition, respiratory failure, and bronchiarctia. It is essential to closely monitor patients possessing these risk factors to prevent the progression towards tuberculosis destroyed lung.
摘要：
■结核病破坏的肺部构成了全球重大的公共卫生挑战，对其相关危险因素和预后知之甚少。我们的研究旨在确定肺结核和结构性肺病中肺结核破坏肺的危险因素。
在2019年1月至2021年12月之间，在中国深圳市第三人民医院进行了一项病例对照研究。我们收集了肺结核和结构性肺病患者的临床数据。病例定义为肺结核破坏肺的患者。对照组未被诊断为肺结核破坏的肺。进行二元逻辑回归。
■在我们的研究中，共有341名患者符合纳入标准,包括182例病例和159例对照。我们发现年龄范围为46-60岁(OR：4.879;95%CI：2.338-10.180)，>60岁（aOR：3.384；95％CI：1.481-7.735）；结核病治疗史（aOR：2.729；95％CI：1.606-4.638）；营养不良（aOR：5.126；95％CI：1.359-19.335）；呼吸衰竭（aOR：5.080；95％CI：1.491-17.306）；支气管损害（aOR：3.4330-95％CI相反，具有正常(aOR:0.207;95%CI:0.116-0.371)或超重BMI(aOR:0.259;95%CI:0.090-0.747)的患者可作为结核病破坏肺的保护因素。
■这项研究表明，肺结核破坏的肺部是肺结核和结构性肺部疾病患者的常见病。结核病致毁肺的独立危险因素被确定为在46-60岁和60岁以上的年龄组内，有结核病治疗史，营养不良,呼吸衰竭,还有支气管.必须密切监测具有这些危险因素的患者，以防止向结核病破坏的肺部发展。
在2019年1月至2021年12月之间，在中国深圳市第三人民医院进行了一项病例对照研究。我们收集了肺结核和结构性肺病患者的临床数据。病例定义为肺结核破坏肺的患者。对照组未被诊断为肺结核破坏的肺。进行二元逻辑回归。
■在我们的研究中，共有341名患者符合纳入标准,包括182例病例和159例对照。我们发现年龄范围为46-60岁(OR：4.879;95%CI：2.338-10.180)，>60岁（aOR：3.384；95％CI：1.481-7.735）；结核病治疗史（aOR：2.729；95％CI：1.606-4.638）；营养不良（aOR：5.126；95％CI：1.359-19.335）；呼吸衰竭（aOR：5.080；95％CI：1.491-17.306）；支气管损害（aOR：3.4330-95％CI相反，具有正常(aOR:0.207;95%CI:0.116-0.371)或超重BMI(aOR:0.259;95%CI:0.090-0.747)的患者可作为结核病破坏肺的保护因素。
■这项研究表明，肺结核破坏的肺部是肺结核和结构性肺部疾病患者的常见病。结核病致毁肺的独立危险因素被确定为在46-60岁和60岁以上的年龄组内，有结核病治疗史，营养不良,呼吸衰竭,还有支气管.必须密切监测具有这些危险因素的患者，以防止向结核病破坏的肺部发展。
