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Abstract：
OBJECTIVE: To assess the effect of gallstone disease on liver parenchyma and the prevalence and extent of liver pathology in cholelithiasis in our population at the Department of General Surgery, Indira Gandhi Institute of Medical Science (IGIMS), Patna.
METHODS: The present prospective observational study was conducted on 100 either-sex patients scheduled for open or laparoscopic cholecystectomy. In all the patients, laboratory and radiological investigations were performed. An undamaged portion of the liver edge around the gallbladder fossa was selected and held by atraumatic forceps. Using sharp scissors, around 1 cm of the liver edge was taken out and sent for histopathological examination.
RESULTS: The mean age of the patients was 39.28 ± 13.73 years. The majority of patients were females (69%). Pain was the predominant clinical feature in 51% of the patients, followed by vomiting (21%), nausea (18%), and indigestion (10%). In 36% of cases, the liver histology was abnormal, including steatosis, fibrosis, cholestasis, portal tract infiltration, and lobular parenchymal infiltration. A significant association was found between the duration of symptoms and abnormal histology findings (P<0.0001).
CONCLUSIONS: Gallstone disease is associated with notable alterations in liver histology, and these changes tend to be more prevalent in individuals with a prolonged duration of symptoms.
METHODS: The present prospective observational study was conducted on 100 either-sex patients scheduled for open or laparoscopic cholecystectomy. In all the patients, laboratory and radiological investigations were performed. An undamaged portion of the liver edge around the gallbladder fossa was selected and held by atraumatic forceps. Using sharp scissors, around 1 cm of the liver edge was taken out and sent for histopathological examination.
RESULTS: The mean age of the patients was 39.28 ± 13.73 years. The majority of patients were females (69%). Pain was the predominant clinical feature in 51% of the patients, followed by vomiting (21%), nausea (18%), and indigestion (10%). In 36% of cases, the liver histology was abnormal, including steatosis, fibrosis, cholestasis, portal tract infiltration, and lobular parenchymal infiltration. A significant association was found between the duration of symptoms and abnormal histology findings (P<0.0001).
CONCLUSIONS: Gallstone disease is associated with notable alterations in liver histology, and these changes tend to be more prevalent in individuals with a prolonged duration of symptoms.
摘要：
目的：评估胆石病对肝实质的影响，以及我们普外科人群胆石症的肝脏病理的患病率和程度，英迪拉·甘地医学科学研究所（IGIMS），巴特那
方法：本前瞻性观察性研究是对100名男女患者进行开腹或腹腔镜胆囊切除术。在所有的病人中，进行了实验室和放射学调查.选择胆囊窝周围肝脏边缘的未受损部分，并用无创伤镊子固定。用锋利的剪刀，取出约1厘米的肝脏边缘，并送去组织病理学检查。
结果：患者的平均年龄为39.28±13.73岁。大多数患者为女性（69%）。51％的患者以疼痛为主要临床特征，其次是呕吐(21%)，恶心（18%），消化不良（10%）。在36%的案例中，肝脏组织学异常,包括脂肪变性,纤维化，胆汁淤积,门静脉浸润，和小叶实质浸润。发现症状持续时间与异常组织学发现之间存在显着相关性（P<0.0001）。
结论：胆石病与肝脏组织学的显著改变有关，这些变化在症状持续时间延长的个体中更普遍。
方法：本前瞻性观察性研究是对100名男女患者进行开腹或腹腔镜胆囊切除术。在所有的病人中，进行了实验室和放射学调查.选择胆囊窝周围肝脏边缘的未受损部分，并用无创伤镊子固定。用锋利的剪刀，取出约1厘米的肝脏边缘，并送去组织病理学检查。
结果：患者的平均年龄为39.28±13.73岁。大多数患者为女性（69%）。51％的患者以疼痛为主要临床特征，其次是呕吐(21%)，恶心（18%），消化不良（10%）。在36%的案例中，肝脏组织学异常,包括脂肪变性,纤维化，胆汁淤积,门静脉浸润，和小叶实质浸润。发现症状持续时间与异常组织学发现之间存在显着相关性（P<0.0001）。
结论：胆石病与肝脏组织学的显著改变有关，这些变化在症状持续时间延长的个体中更普遍。
