PDF(Pubmed)
Abstract：
UNASSIGNED: Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 1 (NLRP1) participates in neuroinflammation. This study aimed to identify serum NLRP as a potential prognostic biomarker of acute intracerebral hemorrhage (ICH).
UNASSIGNED: This prospective cohort study enrolled 145 patients with supratentorial ICH and 51 healthy controls. Serum NLRP1 levels were quantified on admission of all 145 patients, on days 1, 3, 5, 7, and 10 after stroke in 51 of 145 patients and at entry into the study of controls. Poststroke 6-month modified Rankin Scale (mRS) scores of 3-6 signified a poor prognosis.
UNASSIGNED: Compared to controls, patients had prominently increased serum NLRP1 levels until day 10 after ICH, with the highest levels at days 1 and 3. Serum NLRP1 levels were independently correlated with National Institutes of Health Stroke Scale (NIHSS) scores, hematoma volume and six-month mRS scores, and independently predicted six-month bad prognosis. A linear relationship was observed between serum NLRP1 levels and the risk of poor prognosis in a restricted cubic spline. Under the receiver operating characteristic (ROC) curve, serum NLRP levels efficiently discriminated poor prognosis. Serum NLRP1, NIHSS, and hematoma volume were merged into a prognosis prediction model, which was portrayed using a nomogram. Good performance of the model was verified using calibration curve, decision curve, and ROC curve.
UNASSIGNED: Serum NLRP1 levels are elevated during the early period following ICH and are independently related to hemorrhagic severity and poor prognosis, suggesting that serum NLRP1 may represent a promising prognostic biomarker of ICH.
UNASSIGNED: This prospective cohort study enrolled 145 patients with supratentorial ICH and 51 healthy controls. Serum NLRP1 levels were quantified on admission of all 145 patients, on days 1, 3, 5, 7, and 10 after stroke in 51 of 145 patients and at entry into the study of controls. Poststroke 6-month modified Rankin Scale (mRS) scores of 3-6 signified a poor prognosis.
UNASSIGNED: Compared to controls, patients had prominently increased serum NLRP1 levels until day 10 after ICH, with the highest levels at days 1 and 3. Serum NLRP1 levels were independently correlated with National Institutes of Health Stroke Scale (NIHSS) scores, hematoma volume and six-month mRS scores, and independently predicted six-month bad prognosis. A linear relationship was observed between serum NLRP1 levels and the risk of poor prognosis in a restricted cubic spline. Under the receiver operating characteristic (ROC) curve, serum NLRP levels efficiently discriminated poor prognosis. Serum NLRP1, NIHSS, and hematoma volume were merged into a prognosis prediction model, which was portrayed using a nomogram. Good performance of the model was verified using calibration curve, decision curve, and ROC curve.
UNASSIGNED: Serum NLRP1 levels are elevated during the early period following ICH and are independently related to hemorrhagic severity and poor prognosis, suggesting that serum NLRP1 may represent a promising prognostic biomarker of ICH.
摘要：
■核苷酸结合寡聚化结构域样受体家族含pyrin结构域1(NLRP1)参与神经炎症。本研究旨在确定血清NLRP作为急性脑出血（ICH）的潜在预后生物标志物。
■这项前瞻性队列研究纳入了145例幕上ICH患者和51例健康对照。在所有145例患者入院时对血清NLRP1水平进行定量，在145名患者中的51名卒中后第1、3、5、7和10天以及进入对照研究时。卒中后6个月改良的Rankin量表（mRS）评分为3-6表示预后不良。
■与对照组相比，患者血清NLRP1水平显著升高，直至ICH后第10天，在第1天和第3天最高。血清NLRP1水平与美国国立卫生研究院卒中量表(NIHSS)评分独立相关,血肿体积和6个月mRS评分,并独立预测6个月的不良预后。在限制性三次样条中，血清NLRP1水平与不良预后风险之间存在线性关系。在接收器工作特性(ROC)曲线下，血清NLRP水平可有效鉴别不良预后。血清NLRP1，NIHSS，并将血肿体积合并到预后预测模型中，这是用列线图描绘的。使用校准曲线验证了模型的良好性能，决策曲线,和ROC曲线。
■血清NLRP1水平在ICH后早期升高，与出血严重程度和不良预后独立相关，提示血清NLRP1可能是ICH的一个有前景的预后生物标志物.
■这项前瞻性队列研究纳入了145例幕上ICH患者和51例健康对照。在所有145例患者入院时对血清NLRP1水平进行定量，在145名患者中的51名卒中后第1、3、5、7和10天以及进入对照研究时。卒中后6个月改良的Rankin量表（mRS）评分为3-6表示预后不良。
■与对照组相比，患者血清NLRP1水平显著升高，直至ICH后第10天，在第1天和第3天最高。血清NLRP1水平与美国国立卫生研究院卒中量表(NIHSS)评分独立相关,血肿体积和6个月mRS评分,并独立预测6个月的不良预后。在限制性三次样条中，血清NLRP1水平与不良预后风险之间存在线性关系。在接收器工作特性(ROC)曲线下，血清NLRP水平可有效鉴别不良预后。血清NLRP1，NIHSS，并将血肿体积合并到预后预测模型中，这是用列线图描绘的。使用校准曲线验证了模型的良好性能，决策曲线,和ROC曲线。
■血清NLRP1水平在ICH后早期升高，与出血严重程度和不良预后独立相关，提示血清NLRP1可能是ICH的一个有前景的预后生物标志物.
