Abstract：
Superoxide dismutase (SOD) is an important metalloenzyme that catalyzes the dismutation of superoxide radicals (O2˙-) into hydrogen peroxide (H2O2) and oxygen (O2). However, the clinical application of SOD is severely limited due to its structural instability and high cost. Compared with natural enzymes, nanomaterials with enzyme-like activity, nanoenzymes, are more stable, economical and easy to modify and their activity can be adjusted. Certain nanozymes that exhibit SOD-like activity have been created and shown to help prevent illnesses brought about by oxidative stress. These SOD-like nanozymes offer an important solution to the problems associated with the clinical application of SOD. In this review, we briefly introduce neurodegenerative diseases, present the research progress of SOD-like nanoenzymes in the diagnosis and treatment of brain diseases, review their mechanism of action in the treatment and diagnosis of brain diseases, and discuss the shortcomings of the current research with a view to providing a reference for future research. We expect more highly active SOD-like nanoenzymes to be developed with a wide range of applications in the diagnosis and treatment of brain diseases.
摘要：
超氧化物歧化酶（SOD）是一种重要的金属酶，可催化超氧化物自由基（O2•-）向过氧化氢（H2O2）和氧气（O2）的歧化。然而,SOD结构不稳定,成本高,严重限制了其临床应用。与天然酶相比，具有类酶活性的纳米材料，纳米酶，更稳定，经济和易于修改和他们的活动可以调整。已经产生了某些表现出SOD样活性的纳米酶，并显示出有助于预防由氧化应激引起的疾病。这些SOD样纳米酶为与SOD的临床应用相关的问题提供了重要的解决方案。在这次审查中,我们简要介绍神经退行性疾病，介绍了SOD样纳米酶在脑疾病诊断和治疗中的研究进展,回顾它们在脑疾病的治疗和诊断中的作用机制，并讨论了目前研究的不足,以期为今后的研究提供参考。我们期望开发出更高活性的SOD样纳米酶，在脑疾病的诊断和治疗中具有广泛的应用。
