PDF(Pubmed)
Abstract：
We present a rare case of myeloid sarcoma in the stomach of an elderly woman initially diagnosed with anaemia. Myeloid sarcoma, an unusual extramedullary manifestation of acute myeloid leukaemia (AML), primarily affects lymph nodes, bones, spine and skin, with gastrointestinal involvement being infrequent. Despite normal results from the initial endoscopy, a follow-up examination after 4 months revealed multiple submucosal gastric tumours. These developments coincided with worsening of anaemia and an increase in peripheral myeloblasts. Pathological evaluation and immunohistochemical staining confirmed gastric extramedullary infiltration associated with AML. This case highlights the importance of comprehensive diagnostic processes when suspecting leukaemic transformations, especially in myelodysplastic syndrome (MDS). Due to financial constraints, additional critical studies such as cytogenetics and next-generation sequencing were not performed. Nonetheless, this rare case demonstrates the visual observation of rapid progression from MDS to AML and concurrent early myeloid sarcoma development in an elderly patient.
摘要：
我们介绍了一名最初被诊断为贫血的老年妇女的胃中罕见的骨髓肉瘤病例。髓样肉瘤,急性髓性白血病（AML）的异常髓外表现，主要影响淋巴结，骨头,脊柱和皮肤，胃肠道参与很少。尽管最初的内窥镜检查结果正常，4个月后的随访检查显示多个胃粘膜下肿瘤.这些发展与贫血的恶化和外周成髓细胞的增加相吻合。病理评估和免疫组织化学染色证实胃髓外浸润与AML相关。这个案例突出了在怀疑白血病转化时全面诊断过程的重要性，尤其是骨髓增生异常综合征（MDS）。由于资金紧张,没有进行细胞遗传学和下一代测序等其他关键研究.尽管如此，这一罕见病例显示,在1例老年患者中,我们可以通过肉眼观察到从MDS到AML的快速进展以及并发的早期髓系肉瘤发展.
