Abstract：
UNASSIGNED: Since some patients with tick-borne encephalitis (TBE) have pronounced myalgias, and since myositis is reported in Flavivirus diseases such as dengue, we performed systematic search for abnormalities of muscle enzymes in a group of patients in whom the presence of tick-borne encephalitis virus (TBEV) RNA in the first phase of the disease was demonstrated and who developed second phase of TBE.
UNASSIGNED: Total leukocyte and platelet blood counts were determined routinely at the initial examination during the first and the second phase of TBE. Activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine kinase (CK), myoglobin and troponin was determined from the available stored serum specimens; the first and second phase disease specimens were tested simultaneously.
UNASSIGNED: Of 24 patients with biphasic course of TBE, 83% had leukopenia, 65% thrombocytopenia, 83% elevated AST and 4% elevated ALT level. Furthermore, 33% had elevated serum CK, 26% myoglobin and 22% troponin activity; at least one of the muscle enzymes was elevated in 42% of patients. Leukopenia, thrombocytopenia, elevated liver enzymes and elevations of CK and myoglobin were present in the initial phase but resolve later, while troponin abnormalities were also found in the second phase of TBE.
UNASSIGNED: The present study exposes that in addition to previously known leukopenia, thrombocytopenia and increased liver enzymes activity, the initial phase of TBE is relatively often associated also with elevated muscle enzymes. Clinical relevance of these findings remains to be determined.
UNASSIGNED: Total leukocyte and platelet blood counts were determined routinely at the initial examination during the first and the second phase of TBE. Activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine kinase (CK), myoglobin and troponin was determined from the available stored serum specimens; the first and second phase disease specimens were tested simultaneously.
UNASSIGNED: Of 24 patients with biphasic course of TBE, 83% had leukopenia, 65% thrombocytopenia, 83% elevated AST and 4% elevated ALT level. Furthermore, 33% had elevated serum CK, 26% myoglobin and 22% troponin activity; at least one of the muscle enzymes was elevated in 42% of patients. Leukopenia, thrombocytopenia, elevated liver enzymes and elevations of CK and myoglobin were present in the initial phase but resolve later, while troponin abnormalities were also found in the second phase of TBE.
UNASSIGNED: The present study exposes that in addition to previously known leukopenia, thrombocytopenia and increased liver enzymes activity, the initial phase of TBE is relatively often associated also with elevated muscle enzymes. Clinical relevance of these findings remains to be determined.
摘要：
■由于一些蜱传脑炎（TBE）患者有明显的肌痛，由于在登革热等黄病毒病中报道了肌炎，我们对一组患者的肌肉酶异常进行了系统搜索,这些患者在疾病的第一阶段中发现了蜱传脑炎病毒(TBEV)RNA,并且出现了TBE的第二阶段.
■在TBE的第一阶段和第二阶段的初始检查中常规测定总白细胞和血小板血细胞计数。天冬氨酸转氨酶(AST)活性,丙氨酸氨基转移酶（ALT），肌酸激酶（CK），肌红蛋白和肌钙蛋白是从可用的储存血清标本中确定的;同时测试第一和第二阶段疾病标本。
■在24例TBE双相病程患者中，83%有白细胞减少症,65%血小板减少症,83%升高的AST和4%升高的ALT水平。此外，33%有血清CK升高，26％的肌红蛋白和22％的肌钙蛋白活性；42％的患者中至少一种肌肉酶升高。白细胞减少症,血小板减少症,升高的肝酶和CK和肌红蛋白的升高存在于初始阶段，但后来解决，而在TBE的第二阶段也发现了肌钙蛋白异常。
■本研究表明，除了先前已知的白细胞减少症，血小板减少和肝酶活性增加，TBE的初始阶段相对通常还与肌肉酶升高有关。这些发现的临床相关性仍有待确定。
■在TBE的第一阶段和第二阶段的初始检查中常规测定总白细胞和血小板血细胞计数。天冬氨酸转氨酶(AST)活性,丙氨酸氨基转移酶（ALT），肌酸激酶（CK），肌红蛋白和肌钙蛋白是从可用的储存血清标本中确定的;同时测试第一和第二阶段疾病标本。
■在24例TBE双相病程患者中，83%有白细胞减少症,65%血小板减少症,83%升高的AST和4%升高的ALT水平。此外，33%有血清CK升高，26％的肌红蛋白和22％的肌钙蛋白活性；42％的患者中至少一种肌肉酶升高。白细胞减少症,血小板减少症,升高的肝酶和CK和肌红蛋白的升高存在于初始阶段，但后来解决，而在TBE的第二阶段也发现了肌钙蛋白异常。
■本研究表明，除了先前已知的白细胞减少症，血小板减少和肝酶活性增加，TBE的初始阶段相对通常还与肌肉酶升高有关。这些发现的临床相关性仍有待确定。
